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首页> 外文期刊>Vaccine >Advantages to the use of rodent hepadnavirus core proteins as vaccine platforms
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Advantages to the use of rodent hepadnavirus core proteins as vaccine platforms

机译：使用啮齿动物肝炎病毒核心蛋白作为疫苗平台的优势

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The hepatitis B core antigen (HBcAg) has been proposed as a useful particulate carrier platform for poorly immunogenic peptidic and carbohydrate B cell epitopes. However, biochemical and immunologic impediments have plagued this technology. Specifically, the "assembly" problem characterized by the low yield of unstable hybrid particles resulting from the insertion of foreign sequences and the "pre-existing immunity" problem due to the fact that the HBcAg is derived from a human pathogen have limited the development of this carrier technology. As a means of addressing the "pre-existing immunity" problem we have used the core proteins from the rodent hepdnaviruses. A number of advantages to the use of the rodent hepadnaviral core proteins as opposed to the HBcAg for vaccine design were defined including: equal or superior immunogenicity at the T and B cell levels; the use of the rodent core proteins does not compromise the anti-HBc diagnostic assay; the efficacy of the rodent core proteins as vaccine carriers will not be limited by pre-existing anti-HBc antibodies that are present in previously and currently HBV-infected persons; and the HBcAg-specific tolerance present in HBV chronic carriers can be circumvented by the use of the rodent core proteins.
机译：乙型肝炎核心抗原（HBcAg）已被提出作为免疫原性差的肽和碳水化合物B细胞表位的有用的颗粒载体平台。但是，生化和免疫学障碍困扰了该技术。具体地说，由于外源序列的插入而导致不稳定杂种颗粒的低收率以及“ HBcAg来源于人病原体”这一事实导致的“装配”问题和“预先存在的免疫”问题受到了限制。这种载体技术。作为解决“预先存在的免疫力”问题的一种方法，我们使用了来自啮齿动物肝病毒的核心蛋白。相对于HBcAg，使用啮齿类肝炎病毒核心蛋白进行疫苗设计有许多优点，包括：在T细胞和B细胞水平具有相同或更高的免疫原性;啮齿动物核心蛋白的使用不会影响抗HBc诊断测定;啮齿动物核心蛋白作为疫苗载体的功效将不受先前和目前感染HBV的人中已有的抗HBc抗体的限制;并且通过使用啮齿动物核心蛋白可以避免存在于HBV慢性携带者中的HBcAg特异性耐受性。

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