Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

Yerkovich ST; Rowe J; Richmond P; Suriyaarachchi D; Heaton T; Hollams E; Ladyman C; Serralha M; Sadowska A; Loh R; Wesselingh SL; Sly PD; Holt PG

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Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

机译：评估麻疹腮腺炎风疹和水痘疫苗对婴儿的效力和潜在的免疫调节作用

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This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group, MMR vaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any "bystander" effects of the vaccines on systemic immunity.

机译：这项研究比较了单独或与水痘（MMR和V）联合给婴儿使用的麻疹腮腺炎风疹（MMR）疫苗的效力和免疫调节作用。在另一组中，MMR疫苗接种延迟了42天，以分析对全身免疫功能潜在成熟的潜在影响。对疫苗的免疫力评估表明抗体产生稳定，并且混合了Th1 / Th2记忆，并且疫苗组之间或接种MMR疫苗的组之间没有显着差异。对植物血凝素和破伤风类毒素的细胞因子反应的并行分析未发现疫苗对全身免疫的任何“旁观者”效应。

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《Vaccine》 |2007年第10期|共7页
作者
Yerkovich ST; Rowe J; Richmond P; Suriyaarachchi D; Heaton T; Hollams E; Ladyman C; Serralha M; Sadowska A; Loh R; Wesselingh SL; Sly PD; Holt PG;
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中图分类卫生标准、卫生检查、医药管理;
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1. Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants [J] . Yerkovich ST, Rowe J, Richmond P, Vaccine . 2007,第10期

机译：评估麻疹腮腺炎风疹和水痘疫苗对婴儿的效力和潜在的免疫调节作用
2. Immunogenicity and safety of a combined measles, mumps, rubella and varicella live vaccine (ProQuad (R)) administered concomitantly with a booster dose of a hexavalent vaccine in 12-23-month-old infants [J] . Deichmann Klaus A., Ferrera Giuseppe, Tran Clement, Vaccine . 2015,第20期

机译：麻疹，腮腺炎，风疹和水痘活疫苗（ProQuad（R））与加强剂量的六价疫苗同时接种在12-23个月大的婴儿中的免疫原性和安全性
3. Antibody persistence and booster vaccination of a fully liquid hexavalent vaccine coadministered with measles/mumps/rubella and varicella vaccines at 15-18 months of age in healthy South African infants [J] . MadhiS.A., KoenA., CutlandC., The Pediatric infectious disease journal . 2013,第8期

机译：在南非健康婴儿中，在15至18个月大时与麻疹/腮腺炎/风疹和水痘疫苗联合使用的全液体六价疫苗的抗体持久性和加强疫苗接种
4. Pre-and Post vaccine Measles Antibody Levels in Infants: An Evaluation of Routine Immunization in Nigeria [C] . Fowotade A., Nwabuisi C., Bakare R.A., World Congress of the World Society for Pediatric Infectious Diseases . 2014

机译：婴儿的前后疫苗麻疹抗体水平：尼日利亚常规免疫的评价
5. Parental decision-making for the varicella and measles, mump and rubella vaccines. [D] . Niederhauser, Victoria Page. 1999

机译：父母对水痘和麻疹，腮腺炎和风疹疫苗的决策。
6. 2467. Timeliness of Childhood Vaccination With the Combination Measles–Mumps–Rubella–Varicella Vaccine vs. the Separate Measles–Mumps–Rubella and Varicella Vaccines in the United States [O] . Lara Wolfson, Shikha Surati, Elizabeth Richardson, -1

机译：2467.在美国儿童接种麻疹-腮腺炎-风疹-水痘混合疫苗的及时性与单独的麻疹-腮腺炎-风疹和水痘疫苗的比较
7. 2467. Timeliness of Childhood Vaccination With the Combination Measles–Mumps–Rubella–Varicella Vaccine vs. the Separate Measles–Mumps–Rubella and Varicella Vaccines in the United States [O] . Lara Wolfson, Shikha Surati, Elizabeth Richardson, 2018

机译：2467.儿童疫苗接种与麻疹组合 - Mumps-rubella-Varicella疫苗与美国单独的麻疹 - 腮腺炎 - 风疹和美国水痘疫苗接种的及时性

Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

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