Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus.

Vashisht K; Goldberg TL; Husmann RJ; Schnitzlein W; Zuckermann FA

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Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus.

机译：鉴定猪繁殖与呼吸综合征病毒北美基因型糖蛋白5中存在的免疫优势T细胞表位。

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Ninty-six pentadecapeptides spanning glycoprotein 5 (GP5) of porcine reproductive and respiratory virus (PRRSV) were screened for their ability to elicit a recall interferon-gamma response from peripheral blood mononuclear cells isolated from 22 pigs infected with up to two genetically divergent PRRSV strains. Two distinct regions (amino acid residues 117-131, LAALICFVIRLAKNC, and 149-163, KGRLYRWRSPVII/VEK) appeared to contain immunodominant T-cell epitopes based on their ability to stimulate above average numbers of interferon-gamma secreting cells as compared to other GP5 peptides. A survey of PRRSV isolates indicated that these two sites are relatively conserved with at most a two amino acid variation and thus should be considered for incorporation into a multi-valent vaccine against PRRS.

机译：筛选了跨猪生殖和呼吸道病毒（PRRSV）糖蛋白5（GP5）的96种五肽，它们能够从22头猪中分离出的外周血单核细胞引起召回干扰素-γ反应，该猪感染了多达两种遗传上不同的PRRSV株。两个不同区域（氨基酸残基117-131，LAALICFVIRLAKNC和149-163，KGRLYRWRSPVII / VEK）似乎含有免疫显性T细胞表位，这是因为它们与其他GP5相比，具有刺激产生高于平均水平的干扰素-γ分泌细胞的能力。肽。对PRRSV分离株的调查表明，这两个位点相对保守，最多具有两个氨基酸变异，因此应考虑将其掺入抗PRRS的多价疫苗中。

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《Vaccine》 |2008年第36期|共7页
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Vashisht K; Goldberg TL; Husmann RJ; Schnitzlein W; Zuckermann FA;
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中图分类卫生标准、卫生检查、医药管理;
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1. Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus. [J] . Vashisht K, Goldberg TL, Husmann RJ, Vaccine . 2008,第36期

机译：鉴定猪繁殖与呼吸综合征病毒北美基因型糖蛋白5中存在的免疫优势T细胞表位。
2. In silico prediction and ex vivo evaluation of potential T-cell epitopes in glycoproteins 4 and 5 and nucleocapsid protein of genotype-I (European) of porcine reproductive and respiratory syndrome virus. [J] . Diaz I., Pujols J., Ganges L., Vaccine . 2009,第41期

机译：猪生殖和呼吸综合症病毒的基因型I（欧洲）的糖蛋白4和5以及核衣壳蛋白中可能的T细胞表位的计算机模拟预测和离体评估。
3. Identification of porcine alveolar macrophage glycoproteins involved in infection of porcine respiratory and reproductive syndrome virus. [J] . Wissink EH, van Wijk HA, Pol JM, Archives of virology . 2003,第1期

机译：鉴定涉及猪呼吸道和生殖综合症病毒感染的猪肺泡巨噬细胞糖蛋白。
4. Attenuation of a virulent North American porcine reproductive and respiratory syndrome (PRRS) virus isolate on CDl63-expressing cell lines, and demonstration of efficacy against a heterologous challen [C] . Jay G. Calvert, Marcia L. Keith, Lucas P. Taylor, Annual Meeting of The American Association of Swine Veterinarians . 2012

机译：衰减毒性北美猪生殖和呼吸综合征（PRRS）病毒在CDL63表达的细胞系中分离，并对异源呼吸的功效示范
5. Characterization of glycoprotein 4 of porcine reproductive and respiratory syndrome virus. [D] . Bachand, Aimee. 2004

机译：猪繁殖与呼吸综合征病毒糖蛋白4的表征。
6. Comparative pathogenesis of type 1 (European genotype) and type 2 (North American genotype) porcine reproductive and respiratory syndrome virus in infected boar [O] . Kiwon Han, Hwi Won Seo, Changhoon Park, 2013

机译：感染公猪中1型（欧洲基因型）和2型（北美基因型）猪繁殖与呼吸综合征病毒的比较发病机理
7. Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes. [O] . Nan Jiang, Huan Jin, Yi Li, 2017

机译：鉴定猪繁殖与呼吸综合征病毒的非结构蛋白11中的新型线性B细胞表位，其在两种基因型中都是保守的。

Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus.

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