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Lack of contact transmission of recombinant Marek's disease virus type 1 expressing the fusion protein of Newcastle disease virus

机译：缺乏表达新城疫病毒融合蛋白的重组马立克氏病病毒1型的接触传播

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摘要

To clarify the level of excretion of a recombinant Marek's disease virus type 1 (rMDV1) that confers good protection in chickens against both Marek's and Newcastle diseases, even in the presence of maternal antibodies, contact transmission tests were conducted. Naive chickens kept in the same cage or room with chickens inoculated with rMDV1 did not produce antibodies against MDV1 or the fusion protein of Newcastle disease virus. Moreover, the rMDV1 was not isolated from the dander of chickens inoculated with rMDV1. Even under the stressful conditions of forced molting and a high temperature environment. rMDV1 was not isolated from the dander of inoculated birds. The viral DNA, however, was detected from the dander of chickens inoculated with rMDV1 as well as a commercial vaccine. These findings indicate that dander from chickens inoculated with rMDV1 includes viral DNA, but does not contain infectious virus.
机译：为了阐明重组马立克氏病病毒1型（rMDV1）的排泄水平，即使在存在母体抗体的情况下，也能对鸡提供良好的保护以抵抗马立克氏病和新城疫，因此进行了接触传播测试。与rMDV1疫苗一起接种在同一笼子或房间中的幼稚鸡未产生针对MDV1或新城疫病毒融合蛋白的抗体。而且，没有从接种了rMDV1的鸡的皮屑中分离出rMDV1。即使在强制蜕皮和高温环境下的压力条件下。 rMDV1不是从被接种禽鸟的皮屑中分离出来的。但是，从接种rMDV1的鸡皮屑以及市售疫苗中检出了病毒DNA。这些发现表明，用rMDV1接种的鸡的皮屑包括病毒DNA，但不含传染性病毒。

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