The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines

von Hunolstein C; Mariotti S; Teloni R; Alfarone G; Romagnoli G

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The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines

机译：含有CpG基序的合成寡聚脱氧核苷酸的佐剂作用将抗流感嗜血杆菌b型糖缀合物转化为有效的抗多糖和抗载体多价疫苗

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Synthetic oligodeoxynucleotides containing CpG immunostimulatory sequences (ISS) have been shown to act as potent adjuvants of type 1 immune responses when co-administered with protein or peptide vaccines. We have recently shown that ISS can increase the anti-polysaccharide (CHO) and anti-tetanus toroid (TT) or anti-diphtheria (CRM) toroid antibody levels if used as adjuvant of anti-Haemophilus influenzae type b (Hib) CHO vaccine conjugated with TT or CRM. The analysis of anti-TT and anti-CRM IgG subclasses showed a significant increase in IgG2a. IgG2b and/or IgG3 in the presence of ISS. Anti-TT and anti-CRM antibodies were shown to neutralize the activity of both the tetanus and diphtheria toxin in vivo or in vitro tests respectively. These data show that ISS have the potential to increase host antibody response against both the CHO and the protein component of a conjugated vaccine, and encourage the investigation to identify strategies of vaccination with schedules aimed at the valuation of protein carriers as protective immunogens.

机译：与蛋白质或肽疫苗同时使用时，已证明含有CpG免疫刺激序列（ISS）的合成寡聚脱氧核苷酸可作为有效的1型免疫应答佐剂。我们最近表明，ISS可用作结合了抗b型流感嗜血杆菌（Hib）CHO疫苗的佐剂，可以提高抗多糖（CHO）和抗破伤风环形（TT）或抗白喉（CRM）环形抗体的水平TT或CRM。抗TT和抗CRM IgG亚类的分析显示IgG2a显着增加。 ISS存在下的IgG2b和/或IgG3。已显示抗TT和抗CRM抗体分别在体内或体外试验中和破伤风和白喉毒素的活性。这些数据表明，ISS具有增加针对CHO和结合疫苗中蛋白质成分的宿主抗体反应的潜力，并鼓励开展调查，以计划针对蛋白质载体作为保护性免疫原的评估方案确定疫苗接种策略。

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《Vaccine》 |2001年第24期|共9页
作者
von Hunolstein C; Mariotti S; Teloni R; Alfarone G; Romagnoli G;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Cpg motifs; Glycoconjugate vaccines; Anti-toxin antibodies; Protein conjugate vaccines; Immune-responses; Bacterial-dna; Immunostimulatory dna; Diphtheria-toxin; In-vivo; Tetanus; Antibodies; Immunogenicity; Activation;

机译：Cpg基序;糖结合疫苗;抗毒素抗体;蛋白质结合疫苗;免疫应答;细菌-dna;免疫刺激性dna;白喉毒素;体内;破伤风;抗体;免疫原性;激活;

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1. The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines [J] . von Hunolstein C, Mariotti S, Teloni R, Vaccine . 2001,第23a24期

机译：含有CpG基序的合成寡聚脱氧核苷酸的佐剂作用将抗流感嗜血杆菌b型糖缀合物转化为有效的抗多糖和抗载体多价疫苗
2. Immunogenicity of anti-Haemophilus influenzae type b CRM197 conjugate following mucosal vaccination with oligodeoxynucleotide containing immunostimulatory sequences as adjuvant [J] . Mariotti S, Teloni R, von Hunolstein C, Vaccine . 2002,第17a18期

机译：抗乙型流感嗜血杆菌CRM197偶联物的黏膜接种后，含有免疫刺激序列的寡脱氧核苷酸作为佐剂的免疫原性
3. In vitro and in vivo evaluations of human papillomavirus type 16 (HPV16)-derived peptide-loaded dendritic cells (DCs) with a CpG oligodeoxynucleotide (CpG-ODN) adjuvant as tumor vaccines for immunotherapy of cervical cancer [J] . WangH.L., XuH., LuW.H., Archives of gynecology and obstetrics. . 2014,第1期

机译：带有CpG寡脱氧核苷酸（CpG-ODN）佐剂作为宫颈癌免疫治疗的肿瘤疫苗的人乳头瘤病毒16型（HPV16）衍生肽负载树突状细胞（DCs）的体外和体内评估
4. A LIQUID STABLE BIOLOGICAL ACTIVE SEMI-SYNTHETIC GLYCOCONJUGATE VACCINE AGAINST HAEMOPHILUS INFLUENZAE TYPE b [C] . Madhu Emmadi, Marilda P. Lisboa, Bopanna Monnanda International Carbohydrate Symposium . 2018

机译：一种液体稳定的生物活性半合成糖醌疫苗，对嗜血杆菌流感型B型
5. Incorporation of CpG oligodeoxynucleotides into alpha2-macroglobulin: Development of a novel vaccine adjuvant delivery mechanism [D] . Anderson, Ryan Berger. 2007

机译：将CpG寡聚脱氧核苷酸掺入α2-癌胶质蛋白：新型疫苗佐剂递送机制的开发
6. Prevention and Treatment of Cutaneous Leishmaniasis in Primates by Using Synthetic Type D/A Oligodeoxynucleotides Expressing CpG Motifs [O] . Barbara Flynn, Vivian Wang, David L. Sacks, 2005

机译：通过使用表达CpG基序的合成D / A型寡聚脱氧核苷酸预防和治疗灵长类动物皮肤利什曼病。
7. Synthetic oligodeoxynucleotide containing CpG motif induces an anti-polysaccharide type 1-like immune response after immunization of mice with Haemophilus influenzae type b conjugate vaccine [O] . Christina von Hunolstein, Raffaela Teloni, Sabrina Mariotti, 2000

机译：含CpG基序的合成寡聚寡氧核苷酸在用嗜血杆菌型B型缀合物疫苗免疫小鼠后诱导抗多糖型免疫应答
8. CpG Oligodeoxynucleotide and Montanide ISA 51 Adjuvant Combination Enhanced the Protective Efficacy of a Subunit Malaria Vaccine [R] . Kumar, S. , Jones, T. R. , Oakley, M. S. , 2004

机译：CpG寡脱氧核苷酸和montanide Isa 51佐剂组合增强了亚单位疟疾疫苗的保护效力

The adjuvant effect of synthetic oligodeoxynucleotide containing CpG motif converts the anti-Haemophilus influenzae type b glycoconjugates into efficient anti-polysaccharide and anti-carrier polyvalent vaccines

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