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首页> 外文期刊>Vaccine >Epidermal powder immunization using non-toxic bacterial enterotoxin adjuvants with influenza vaccine augments protective immunity
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Epidermal powder immunization using non-toxic bacterial enterotoxin adjuvants with influenza vaccine augments protective immunity

机译：使用无毒细菌肠毒素佐剂和流感疫苗进行表皮粉末免疫可增强保护性免疫

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摘要

The non-toxic B subunit of cholera toxin (CTB) and E. coli heat-labile toxin mutant proteins with reduced toxicity (LTR72) or no toxicity (LTK63) were used as adjuvants for epidermal powder immunization (EPI) with an influenza vaccine. When administered by EPI, CTB, LTR72 and LTK63 significantly augmented antibody responses to the influenza vaccine and protection against a lethal challenge in a mouse model. The antigen dose could be reduced by 125-fold. These adjuvants were well-tolerated both locally and systemically following EPI. These results suggest that EPI with influenza vaccine and a non-toxic bacterial enterotoxin hold promise for human vaccination. (C) 2002 Elsevier Science Ltd. All rights reserved. [References: 31]
机译：霍乱毒素（CTB）的无毒B亚基和毒性降低（LTR72）或无毒性（LTK63）的大肠杆菌热不稳定毒素突变蛋白被用作佐剂，用于流感疫苗的表皮粉末免疫（EPI）。当通过EPI给药时，CTB，LTR72和LTK63显着增强了对流感疫苗的抗体反应，并在小鼠模型中提供了针对致命性攻击的保护作用。抗原剂量可减少125倍。在EPI后，这些佐剂在局部和全身均耐受良好。这些结果表明，带有流感疫苗和无毒细菌肠毒素的EPI有望用于人类疫苗接种。 （C）2002 Elsevier ScienceLtd。保留所有权利。 [参考：31]

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