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首页> 外文期刊>Vaccine >Recombinant vaccine against hepatitis E: duration of protective immunity in rhesus macaques
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Recombinant vaccine against hepatitis E: duration of protective immunity in rhesus macaques

机译：抗戊型肝炎的重组疫苗：恒河猴的保护性免疫持续时间

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摘要

Hepatitis E virus (HEV) is an enterically transmitted virus that causes acute hepatitis. A candidate vaccine containing recombinant HEV capsid protein (56 kDa) expressed in insect cells was shown previously to be highly immunogenic when administered in two doses to rhesus monkeys and to protect them from hepatitis E when challenged with a large intravenous dose of homologous or heterologous HEV. In the present study, the effect of a third dose of the same vaccine lot was evaluated and more importantly, the duration of protection following two doses was determined. Rhesus monkeys vaccinated twice with the 56 kDa capsid protein were challenged with homologous virus 6 or 12 months after the last vaccination: 3 of 4 monkeys challenged 6 or 12 months later, respectively were protected against viral hepatitis. Similarly, all four of the rhesus monkeys given a third dose of vaccine I month prior to challenge were protected against hepatitis. In contrast, all four monkeys given placebo developed hepatitis following challenge. In summary, two doses of HEV vaccine partially protected rhesus monkeys from hepatitis E following intravenous challenge 6 or 12 months after vaccination.
机译：戊型肝炎病毒（HEV）是一种可导致急性肝炎的肠道传播病毒。以前显示了在昆虫细胞中表达的含有重组HEV衣壳蛋白（56 kDa）的候选疫苗在向恒河猴分两剂给药时具有高度免疫原性，并在受到大剂量静脉内同源或异源HEV攻击时能保护它们免受戊型肝炎。在本研究中，评估了第三批相同疫苗的效果，更重要的是，确定了两剂后的保护期。上次接种疫苗后6或12个月，用同源病毒攻击用56 kDa衣壳蛋白接种两次的恒河猴：分别在6或12个月后接受攻击的4只猴子中的3只受到了病毒性肝炎的保护。同样，在攻击前1个月内给予第三剂疫苗的所有四只恒河猴都可以预防肝炎。相比之下，所有接受安慰剂的四只猴子在攻击后都会发展为肝炎。总之，在接种疫苗后6或12个月进行静脉内攻击后，两剂HEV疫苗可部分保护恒河猴免受戊型肝炎感染。

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