Intranasal immunization with recombinant gD2 reduces disease severity andmortality following genital challenge with herpes simplex virus type 2 inguinea pigs

OHagan D.; Goldbeck C.; Ugozzoli M.; Ott G.; Burke RL.

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Intranasal immunization with recombinant gD2 reduces disease severity andmortality following genital challenge with herpes simplex virus type 2 inguinea pigs

机译：用重组gD2进行鼻内免疫可降低2型单纯疱疹病毒豚鼠生殖器攻击后的疾病严重度和死亡率

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The ability of a genetically detoxified mutant of heat labile enterotoxin (LTK63) to act as a mucosal adjuvant following intranasal immunization with recombinant gD2 has previously been reported in mice [Ugozzoli M, O'Hagan DT, Ott GS. Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses. Immunol 1998;93:563-571.]. In the current studies, these observations were extended to the guinea pig model. Immunized guinea pigs were subsequently challenged intravaginally with HSV-2. Intranasal immunization with gD2 and LTK63 induced a significant reduction in disease severity and a reduction in mortality. However, only intramuscular immunization with a potent adjuvant (MF59) induced protection against the incidence of disease. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 30]

机译：先前已在小鼠中报道了用重组gD2进行鼻内免疫后，热不稳定肠毒素（LTK63）的基因解毒突变体充当粘膜佐剂的能力[Ugozzoli M，O'Hagan DT，Ott GS。单纯疱疹病毒2型重组gD2小鼠的鼻内免疫：佐剂对粘膜和血清抗体反应的影响。 Immunol 1998; 93：563-571。在当前的研究中，这些观察已扩展到豚鼠模型。随后用HSV-2对免疫的豚鼠进行阴道内攻击。用gD2和LTK63进行鼻内免疫可显着降低疾病严重程度并降低死亡率。但是，只有用强效佐剂（MF59）进行肌内免疫才能预防疾病的发生。（C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：30]

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《Vaccine》 |1999年第18期|共8页
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OHagan D.; Goldbeck C.; Ugozzoli M.; Ott G.; Burke RL.;
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中图分类卫生标准、卫生检查、医药管理;
关键词
Herpes simplex virus type 2; Guinea pigs; Intravaginal challenge; Ltk63; Toxin b subunit; Antibody responses; Mucosal immunity; Labile; enterotoxin; Synthetic peptide; Escherichia coli; Immunoglobulin a; Nontoxic mutant; Glycoprotein d; Infection;

机译：2型单纯疱疹病毒;几内亚猪;阴道内攻击;Ltk63;毒素b亚基;抗体反应;粘膜免疫;不稳定;肠毒素;合成肽;大肠杆菌;免疫球蛋白a;无毒突变体;糖蛋白d;感染;

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1. 疾病严重度和治疗量对ICU后死亡率的影响 [J] . 关键中德临床肿瘤学杂志（英文版） . 2001,第002期
2. Intranasal immunization with recombinant gD2 reduces disease severity andmortality following genital challenge with herpes simplex virus type 2 inguinea pigs [J] . OHagan D., Goldbeck C., Ugozzoli M., Vaccine . 1999,第18期

机译：用重组gD2进行鼻内免疫可降低2型单纯疱疹病毒豚鼠生殖器攻击后的疾病严重度和死亡率
3. Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs [J] . Richard Brans, Feng Yao BMC Microbiology . 2010,第1期

机译：使用显性阴性重组单纯疱疹病毒（HSV）1型免疫可预防豚鼠的HSV-2生殖器疾病。
4. Prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gD-expressing dominant-negative recombinant HSV-1. [J] . Brans R, Akhrameyeva NV, Yao F The Journal of investigative dermatology. . 2009,第10期

机译：用表达gD的显性阴性重组体HSV-1免疫的小鼠预防1型和2型生殖器单纯疱疹病毒疾病。
5. THE SEVERITY AND RELEVANCE OF PORCINE CIRCOVIRUS TYPE 2 INFECTIONS IN PIGS WITH RESPIRATORY DISEASES FROM HERDS WITH HIGH (CASES) OR LOW (CONTROLS) PNEUMONIA SCORES AT SLAUGHTER [C] . G.J. Wellenberg, F.T. Bouwkamp, P. J. v.d. Wolf, Congress of the International Pig Veterinary Society . 2008

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6. Efficacy of a recombinant herpes virus of turkeys vector vaccine, expressing genes to Newcastle disease virus and Marek's disease virus, in chickens and turkeys against exotic Newcastle disease virus challenge. [D] . Heskett, Eric A. 2003

机译：在鸡和火鸡中表达重组新城疫病毒和马立克氏病病毒基因的火鸡载体疫苗重组疱疹病毒抵抗外来新城疫病毒挑战的功效。
7. Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs. [O] . T C Heineman, B L Connelly, N Bourne, 1995

机译：表达重组疱疹病毒2型糖蛋白D的重组水痘带状疱疹病毒的免疫可降低豚鼠生殖器疱疹的严重程度。
8. Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses. [O] . Ugozzoli, M, O'Hagan, D T, Ott, G S 2001

机译：单纯疱疹病毒2型重组gD2小鼠的鼻内免疫：佐剂对粘膜和血清抗体反应的影响。
9. Amplification of Herpes Simplex Virus Types 1 and 2 and Human Herpes Virus Type 5 Polymerase Gene Segment From Formalin-Fixed Brain Tissue From Alzheimer's Disease Patients [R] . Henrichs, L. E. 2005

机译：从阿尔茨海默病患者的福尔马林固定脑组织扩增1型和2型单纯疱疹病毒和人类疱疹病毒5型聚合酶基因片段

Intranasal immunization with recombinant gD2 reduces disease severity andmortality following genital challenge with herpes simplex virus type 2 inguinea pigs

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