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The influence of host factors and immunogenetics on lymphocyte responsesto Hepagene (R) vaccination

机译：宿主因素和免疫遗传学对淋巴细胞对Hepagene（R）疫苗接种反应的影响

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We have shown that both demographic and immunogenetic factors are involved in the immune responses of Hepagene(R) vaccinated individuals who were persistent nonresponders to 'S' containing hepatitis B vaccines. The HLA-DRB1*0701; DQB1*0202 genotype was found to be associated with a decline of anti-HBs antibodies (anti-HBs) and were frequent in those individuals who remained nonresponders following booster vaccination. Contrary to previously published 'S' vaccination data, Hepagene stimulated T-cell responses showed a lack of correlation with the humoral responses. Limiting dilution analysis demonstrated that the cellular immune response is associated with the kinetics of exposure to Hepagene rather than magnitude of the anti-HBs response. It remains that despite the inclusion of the pre-S proteins 74% nonresponder vaccinated individuals failed to produce > 100 IU/l of anti-HBs. However, these were persistent nonresponders and it was therefore encouraging that two doses of Hepagene did seroconvert (>10 IU/L) 61% of this difficult group. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 43]
机译：我们已经表明，人口统计学和免疫遗传学因素都参与了Hepagene（R）疫苗接种的个体的免疫反应，这些个体对含乙肝疫苗的“ S”持续无反应。 HLA-DRB1 * 0701;发现DQB1 * 0202基因型与抗HBs抗体（抗HBs）的下降有关，并且在加强免疫后仍然无反应的个体中很常见。与先前发表的“ S”疫苗接种数据相反，赫佩涅刺激的T细胞反应显示与体液反应缺乏相关性。极限稀释分析表明，细胞免疫反应与暴露于Hepagene的动力学有关，而不是与抗HBs反应的程度有关。仍然存在，尽管包含pre-S蛋白，但74％无反应者接种疫苗的个体未能产生> 100 IU / l的抗HBs。但是，这些都是顽固的无反应者，因此令人鼓舞的是，两剂Hepagene确实在这一困难组中发生了血清转化（> 10 IU / L）的61％。 （C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：43]

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