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首页> 外文期刊>Vaccine >Intragastric primary infection sensitizes to lung reinfection in a Chlamydia pneumoniae mouse model.
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Intragastric primary infection sensitizes to lung reinfection in a Chlamydia pneumoniae mouse model.

机译：在肺炎衣原体小鼠模型中，胃内原发感染对肺部再感染敏感。

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The most frequently used infection route in Chlamydia pneumoniae animal models is intranasal (i.n.), while the intragastric (i.g.) infection route has not been studied previously. The aim of the present study was to examine the course of Chlamydia pneumoniae infection in mice infected via the i.g. route and to compare the outcome of i.n. reinfection in these mice to i.n. reinfection of primarily i.n. infected mice. C57BL/6JBom mice were used, and the infection was monitored using chlamydial culture, C. pneumoniae PCR and histological examination of several tissues, and antibody measurements. C. pneumoniae was able to disseminate from the gastrointestinal tract to other organs, and i.g. inoculation led to an immunological response. In addition, the primary i.g. challenge made mice more susceptible to i.n. reinfection. In conclusion, the results suggest that the nature of the immune response to a previous C. pneumoniae infection affects the outcome of reinfection.
机译：在肺炎衣原体动物模型中，最常用的感染途径是鼻内（i.n.），而以前未研究过胃内（i.g.）感染途径。本研究的目的是检查经i.g.感染的小鼠的肺炎衣原体感染过程。路线并比较i.n.的结果将这些小鼠再感染到i.n.主要是再感染被感染的小鼠。使用C57BL / 6JBom小鼠，并使用衣原体培养，肺炎衣原体PCR，几种组织的组织学检查以及抗体测量来监测感染。肺炎衣原体能够从胃肠道传播到其他器官，例如接种导致免疫反应。此外，主要挑战使小鼠更容易感染i.n.再感染。总之，结果表明对先前肺炎衣原体感染的免疫反应的性质会影响再感染的结果。

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