Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Delta that expresses SIV Gag protein

Suzuki H; Kidokoro M; Fofana IB; Ohashi T; Okamura T; Matsuo K; Yamamoto N; Shida H

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Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Delta that expresses SIV Gag protein

机译：表达SIV Gag蛋白的新减毒牛痘菌株LC16m8Delta的免疫原性

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We developed the method to efficiently construct recombinant vaccinia viruses based on LC16m8Delta strain that can replicate in mammalian cells but is still safe in human. Immunization in a prime-boost strategy using DNA and LC16m8Delta expressing SIV Gag elicited 7-30-fold more IFN-gamma-producing T cells in mice than that using DNA and non-replicating vaccinia DIs recombinant strain. As the previous study on the DNA-prime and recombinant DIs-boost anti-SIV vaccine showed protective efficacy in themacaque model [Someya K, Ami Y, Nakasone T, Izumi Y, Matsuo K, Horibata S, et al. Induction of positive cellular and humoral responses by a prime-boost vaccine encoded with simian immunodeficiency virus gag/pol. J Immunol 2006;176(3):1784-95], LC16m8Delta would have potential as a better recombinant viral vector for HIV vaccine.

机译：我们开发了一种基于LC16m8Delta菌株可有效构建重组痘苗病毒的方法，该菌株可在哺乳动物细胞中复制，但对人类仍然安全。使用DNA和表达LC16m8Delta的SIV Gag进行的初免-加强免疫策略在小鼠中产生的IFN-γ产生的T细胞比使用DNA和非复制性痘苗DIs重组菌株的免疫细胞多7-30倍。如先前对DNA初免和重组DIs增强型抗SIV疫苗的研究在他们的模型中显示出保护作用[Someya K，Ami Y，Nakasone T，Izumi Y，Matsuo K，Horibata S等。用猿猴免疫缺陷病毒gag / pol编码的初免-加强疫苗诱导阳性细胞和体液反应。 J Immunol 2006; 176（3）：1784-95]，LC16m8Delta具有作为HIV疫苗更好的重组病毒载体的潜力。

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《Vaccine》 |2009年第7期|共6页
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Suzuki H; Kidokoro M; Fofana IB; Ohashi T; Okamura T; Matsuo K; Yamamoto N; Shida H;
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中图分类卫生标准、卫生检查、医药管理;
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1. Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Delta that expresses SIV Gag protein [J] . Suzuki H, Kidokoro M, Fofana IB, Vaccine . 2009,第7期

机译：表达SIV Gag蛋白的新减毒牛痘菌株LC16m8Delta的免疫原性
2. Immunogenicity and safety of the vaccinia virus LC16 m8 Delta Vector expressing SIV Gag under a strong or moderate promoter in a recombinant BCG prime-recombinant vaccinia virus boost protocol. [J] . Sato H., Jing Chen, Isshiki M., Vaccine . 2013,第35期

机译：在重组BCG初免重组牛痘病毒加强协议中，在强或中度启动子下表达SIV Gag的牛痘病毒LC16 m8 Delta载体的免疫原性和安全性。
3. Immunogenicity of viral vector, prime-boost SIV vaccine regimens in infant rhesus macaques: attenuated vesicular stomatitis virus (VSV) and modified vaccinia Ankara (MVA) recombinant SIV vaccines compared to live-attenuated SIV. [J] . Rompay K. K. A. van, Abel K., Earl P., Vaccine . 2010,第6期

机译：病毒载体，初免-加强型SIV疫苗在婴儿恒河猴中的免疫原性：与减毒活病毒SIV相比，减毒水疱性口炎病毒（VSV）和改良牛痘安卡拉（MVA）重组SIV疫苗。
4. Mean Pore Size and Compressive Strain Effects on the Permeability of Collagen-GAG Scaffolds: Cellular Solids Modeling and Experimental Results [C] . B.A. Harley, F.J. OBrien, M.A. Waller, Society for Biomaterials Transaction Annual Meeting vol.29 pt.1; 20060426-29; Pittsburgh,PA(US) . 2006

机译：平均孔径和压缩应变对胶原蛋白-GAG支架渗透性的影响：细胞固体模型和实验结果
5. Identification of immunogenic candidate antigens, proteins expressed in vivo, and development of attenuated strains of Flavobacterium psychrophilum for vaccine development [D] . LaFrentz, Benjamin Ryan 2007

机译：鉴定免疫原性候选抗原，体内表达的蛋白质以及开发用于疫苗开发的嗜冷黄杆菌减毒株
6. Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8+ T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag [O] . Sachin Gupta, James M. Termini, Francesca N. Raffa, 2014

机译：将融合HIV-1 Gag抗原引入多三聚体CD40L构建体的融合蛋白进行疫苗接种可增强CD8 + T细胞反应并能抵抗由Vaccinia-Gag引起的病毒攻击
7. Immunogenicity of viral vector, prime-boost SIV vaccine regimens in infant rhesus macaques: Attenuated vesicular stomatitis virus (VSV) and modified vaccinia Ankara (MVA) recombinant SIV vaccines compared to live-attenuated SIV [O] . Koen K.A. Van Rompay, Kristina Abel, Patricia Earl, 2010

机译：病毒载体的免疫原性，婴幼儿绵羊猕猴的Prime-Boost SIV疫苗方案：与活化的SIV相比，减毒的脉湿性口炎病毒（VSV）和改性痘苗的Ankara（MVA）重组SIV疫苗

Immunogenicity of newly constructed attenuated vaccinia strain LC16m8Delta that expresses SIV Gag protein

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