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首页> 外文期刊>Vaccine >Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Sardinia (Italy)
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Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Sardinia (Italy)

机译：撒丁岛（意大利）妇女中人乳头瘤病毒（HPV）的流行病学和基因型分布

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The human papillomavirus (HPV) infection is necessary for the development of cervical cancer. Our study aims to evaluate the rate of HPV circulation in our population, to identify the prevalent genotypes and to establish correlation with cervical abnormalities. Furthermore, the awareness of women about HPV issues was investigated. This study included 864 women attending the Oncologic Prevention Service for their routine Pap test screening or the Health Promotion Mother-Child Service for counselling about sexual activity, from July 2006 to September 2007. All the participants gave their informed consent to be enrolled in the study and were invited to fill in a questionnaire about the socio-cultural state, sexual activity and awareness about HPV. Thewomen samples were tested for HPV-DNA and HPV genotypes: any type of HPV-DNA was detected in 31.0% of the women; single or multiple infections sustained by HPV-16 or HPV-18 represented 43.5% of all HPV infections, accounting for infections in 11.8% of the recruited women. The HPV and high-risk HPV (HR-HPV) prevalence significantly declined in women older than 46 years. The Pap test result was available in 490 women; 48.1% of the Pap test positive women had also an HPV infection and among these 22.7% were infected by HPV-16 and/or HPV-18 genotype, while 51.9% (94/181) were HPV negative. The analysis by binary logistic regression showed that genotype 16 and/or 18 is a risk factor for the Pap positive test with a odds ratio (OR) of 2.9 (95% C.I. 1.4-5.9)and 3.6 (95% C.l. 1.58-8.42) respectively, while age is a protective factor (OR 0.97, C.I. 95% 0.96-0.99); furthermore, the mean age at the first sexual intercourse and the mean number of partners since the beginning of sexual activity, were statistically associated with the risk of HPV infection. More than half of women were aware about HPV, its sexual transmission and of its correlation with cervix cancer. Our findings evidenced that HPV infection is frequent in women aged 18-46 years in Sardinia andparticularly that 16 and 18 HPV genotypes are detectable in more than 40% of the infected women. The proportion of women informed about HPV issues is sufficient to guarantee an aware approach to HPV vaccination.
机译：人类乳头瘤病毒（HPV）感染是宫颈癌发展所必需的。我们的研究旨在评估我们人群中HPV循环的速度，确定流行的基因型并建立与宫颈异常的相关性。此外，还调查了妇女对HPV问题的认识。该研究包括2006年7月至2007年9月参加常规预防巴氏涂片检查或参加健康促进母婴服务以进行性活动咨询的864名妇女。所有参与者均表示知情同意参加该研究。并应邀填写有关社会文化状态，性活动和对HPV意识的问卷。对妇女样本进行了HPV-DNA和HPV基因型测试：在31.0％的女性中检出了任何类型的HPV-DNA。 HPV-16或HPV-18持续单发或多发感染占所有HPV感染的43.5％，占新招募妇女的11.8％。 46岁以上的女性的HPV和高危HPV（HR-HPV）患病率显着下降。巴氏试验的结果可用于490名女性中。 Pap检测阳性的女性中有48.1％也有HPV感染，其中22.7％的女性被HPV-16和/或HPV-18基因型感染，而HPV阴性的女性中有51.9％（94/181）。二元logistic回归分析显示基因型16和/或18是Pap阳性试验的危险因素，优势比（OR）为2.9（95％CI 1.4-5.9）和3.6（95％Cl 1.58-8.42）年龄是保护因素（OR 0.97，CI 95％0.96-0.99）;而且，第一次性交的平均年龄和自性活动开始以来的平均伴侣数与HPV感染的风险有统计学联系。超过半数的妇女了解HPV，其性传播及其与子宫颈癌的相关性。我们的研究结果表明，撒丁岛18-46岁女性中HPV感染很常见，特别是在40％以上的感染女性中可检测到16和18种HPV基因型。被告知有关HPV问题的妇女比例足以确保对HPV疫苗接种采取有意识的方法。

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