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Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

机译：一种新的研究性四价脑膜炎球菌结合疫苗的化学作用，该疫苗在所有年龄段均具有免疫原性

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Meningococcal disease is a serious medical condition that can prove fatal within hours in otherwise healthy individuals. Disease incidence is highest in infants, yet there is no broadly protective quadrivalent vaccine that covers this age group. A new investigational quadrivalent meningococcal glycoconjugate vaccine against meningococcal serogroups A, C, W-135, and Y (MenACWY-CRM, Novartis Vaccines, Siena, Italy), has been developed to meet this medical need. This article discusses the vaccine technology behind MenACWY-CRM, focusing on the heritage of CRM sub(197), the conjugation chemistry, the sizing of the oligosaccharides, and the advantages that these may confer on the vaccine. We highlight the differences between available vaccines and look at the clinical experience with vaccines against other diseases, demonstrating the importance of each component to the immunogenicity of conjugate vaccines. The specific technological approach, including conjugation of meningococcal oligosaccharides of defined length to the CRM sub(197) protein, has led to a vaccine that has the potential to provide broad meningococcal protection against serogroups A, C, W-135, and Y for all ages.
机译：脑膜炎球菌病是一种严重的医学疾病，对于其他一些健康的个体，数小时之内就可能致命。婴儿的疾病发病率最高，但没有涵盖该年龄段的广泛保护性四价疫苗。针对这种医学需要，已开发出一种针对脑膜炎球菌血清A，C，W-135和Y的新的研究性四价脑膜炎球菌糖缀合物疫苗（MenACWY-CRM，诺华疫苗，意大利锡耶纳）。本文讨论了MenACWY-CRM背后的疫苗技术，重点是CRM sub（197）的传承，缀合化学，寡糖的大小确定以及这些优点可赋予疫苗。我们着重介绍了可用疫苗之间的差异，并研究了针对其他疾病的疫苗的临床经验，证明了每种成分对结合疫苗免疫原性的重要性。具体的技术方法，包括将一定长度的脑膜炎球菌寡糖与CRM Sub（197）蛋白结合，已导致疫苗具有为所有人群提供针对血清群A，C，W-135和Y的广泛脑膜炎球菌保护的潜力年龄。

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