...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination
【24h】

Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination

机译：调查认为对疫苗无反应的医护人员对乙肝表面抗原的记忆B细胞反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Up to 20% of health care workers are considered as non-responders to hepatitis B vaccination (anti-HBs < 10 mUI/ml in serum). We have explored memory B cells differentiated in vitro into anti-HBs antibody-secreting cells (anti-HBs-SCs) by ELISPOT assay. Anti-HBs-SCs were detected in vaccinated responders (n = 11) and non-responders (n = 10) but IgG anti-HBs-SCs were significantly lower in the non-responder group (p < 0.001). Low amounts of HBs antibodies were also quantified by ELISA in non-responders' sera. These results indicate that a suboptimal B cell response exists in non-responders to HBV vaccination. This B cell response may mediate a protection against clinically significant breakthrough hepatitis B infection
机译：多达20％的医护人员被视为对乙肝疫苗接种无反应（血清中抗HBs <10 mUI / ml）。我们已经通过ELISPOT分析探索了在体外分化为抗HBs抗体分泌细胞（anti-HBs-SCs）的记忆B细胞。在已接种疫苗的应答者（n = 11）和无应答者（n = 10）中检测到抗HBs-SCs，但是在无应答者组中IgG抗HBs-SCs显着降低（p <0.001）。还通过ELISA在非应答者血清中定量了少量的HBs抗体。这些结果表明，对HBV疫苗接种无反应的B细胞反应欠佳。这种B细胞反应可能介导了针对临床意义重大的突破性乙型肝炎感染的保护作用

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号