Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine

Dauner Joseph G.; Pan Yuanji; Hildesheim Allan; Harro Clayton; Pinto Ligia A. .

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Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine

机译：接受无佐剂HPV16 L1 VLP疫苗的女性中HPV特异性记忆B细胞和全身抗体应答的特征

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Human papillomavirus (HPV)-specific antibodies are proposed to be the correlate of protection afforded by HPV L1 virus-like particle (VLP) vaccines Previous studies have characterized the systemic antibody response to immunization in terms of both the quantity and the ability to neutralize HPV Here, we have adapted a generalized memory B cell ELISPOT to the HPV16 system and expanded the analysis of the systemic antibody response to include an avidity measurement of HPV 1.1 VIP-specific antibodies We show the results of the memory B cell ELISPOT significantly correlated with IgG and neutralizing antibody titers, but not with the avidity measurement This is the first comprehensive study to correlate a variety of humoral aspects potentially associated with protective immunity following vaccination with a HPV16 L1 VLP vaccine

机译：人乳头瘤病毒（HPV）特异性抗体被认为是HPV L1病毒样颗粒（VLP）疫苗所提供的保护作用的相关性先前的研究已经从数量和中和HPV的能力两方面对全身性抗体对免疫的反应进行了表征。在这里，我们将广义记忆B细胞ELISPOT适应了HPV16系统，并扩展了全身抗体反应的分析，以包括对HPV 1.1 VIP特异性抗体的亲和力测量。我们显示了记忆B细胞ELISPOT与IgG显着相关的结果和中和抗体滴度，但不进行亲和力测量这是第一个将HPV16 L1 VLP疫苗接种后可能与保护性免疫相关的多种体液相关的综合研究

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《Vaccine》 |2010年第33期|共7页
作者
Dauner Joseph G.; Pan Yuanji; Hildesheim Allan; Harro Clayton; Pinto Ligia A. .;
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正文语种 eng
中图分类医学免疫学;
关键词
immunoglobulin G: IgG; neutralizing antibody; HPV16 L1 VLP vaccine: immunologic-drug; immunostimulant-drug; vaccine; phase II clinical trial; dosa; humoral response;

机译：免疫球蛋白G：IgG;中和抗体;HPV16 L1 VLP疫苗：免疫药物;免疫刺激药物;疫苗;II期临床试验;dosa;体液反应;

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1. Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine [J] . Dauner Joseph G., Pan Yuanji, Hildesheim Allan, Vaccine . 2010,第33期

机译：接受无佐剂HPV16 L1 VLP疫苗的女性中HPV特异性记忆B细胞和全身抗体应答的特征
2. Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only [J] . Giannini SL, Moris P, Morel S, Vaccine . 2006,第33a34期

机译：与仅铝盐相比，使用MPL /铝盐组合（AS04）配制的HPV16 / 18 L1 VLP疫苗可增强体液和记忆B细胞免疫
3. HPV16/18 L1 VLP vaccine induces cross-neutralizing antibodies that may mediate cross-protection [J] . Kemp Troy J., Hildesheim Allan, Safaeian Mahboobeh, Vaccine . 2011,第11期

机译：HPV16 / 18 L1 VLP疫苗诱导交叉中和抗体，可能介导交叉保护
4. Parasite-induced B-cell apoptosis results in loss of specific protective anti-trypanosome antibody responses, and abolishment of vaccine induced protective memory responses. [C] . Magez S, Bockstal V, Brombacher F, International Congress of Parasitology . 2010

机译：寄生虫诱导的B细胞凋亡导致损失特异性保护性抗锥虫组抗体反应，以及废除疫苗诱导的保护性记忆反应。
5. Identification and characterization of a heparin-binding region on the L1 major capsid protein of recombinant human papillomavirus virus-like particles and its role in interactions of VLPs with cells. [D] . Joyce, Joseph Gerard. 1998

机译：重组人乳头瘤病毒病毒样颗粒的L1主要衣壳蛋白上肝素结合区的鉴定和表征及其在VLP与细胞相互作用中的作用。
6. Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine [O] . Joseph G. Dauner, Yuanji Pan, Allan Hildesheim, -1

机译：HPV特异性记忆B细胞的表征和妇女中的妇女中的全身抗体反应接受unadjuvanted HPV16 L1 VLP疫苗
7. Mucosal Vaccination with a Recombinant Salmonella typhimurium Expressing Human Papillomavirus Type 16 (HPV16) L1 Virus-like Particles (VLPs) or HPV16 VLPs Purified from Insect Cells Inhibits the Growth of HPV16-Expressing Tumor Cells in Mice [O] . Revaz Véronique, Benyacoub Jalil, Kast W.Martin, 2001

机译：重组鼠伤寒沙门氏菌表达人乳头瘤病毒16型（HPV16）L1病毒样颗粒（VLP）或从昆虫细胞中纯化的HPV16 VLP的粘膜疫苗接种抑制了表达HPV16的肿瘤细胞在小鼠中的生长。

Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine

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