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首页> 外文期刊>Vaccine >Effect of rice-expressed amyloid beta in the Tg2576 Alzheimer's disease transgenic mouse model
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Effect of rice-expressed amyloid beta in the Tg2576 Alzheimer's disease transgenic mouse model

机译：水稻表达的淀粉样β蛋白在Tg2576阿尔茨海默氏病转基因小鼠模型中的作用

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One of the main hallmarks of Alzheimer's disease (AD) is senile plaques composed of amyloid beta (A beta). We developed a new edible vaccine: rice expressing GFP-A beta 42. In a previous report, we described the production of anti-A beta antibodies in B6 mice fed A beta rice mixed with cholera toxin B subunit (CTB). In this report, we investigated whether A beta rice had therapeutic effects in the Tg2576 AD model mice. The anti-A beta antibody titer was increased and levels of intracerebral A beta (soluble and insoluble) and serum A beta decreased. Because the value of IgG1/IgG2a in the lap feeding group was >1, immunization via A beta rice may induce a non-inflammatory Th2 reaction. We also found that the A beta vaccine improved memory, as assessed in a Y-maze test. The number of arm entries in the Y-maze test was lower in the A beta feeding group than in the control group. These results suggest that the new edible vaccine A beta rice may have therapeutic effects in AD
机译：阿尔茨海默氏病（AD）的主要标志之一是由淀粉样蛋白β（A beta）组成的老年斑。我们开发了一种新的可食用疫苗：表达GFP-A beta 42的水稻。在以前的报告中，我们描述了在A6水稻与霍乱毒素B亚基（CTB）混合喂养的B6小鼠中生产抗A beta抗体。在此报告中，我们调查了Aβ稻米是否对Tg2576 AD模型小鼠具有治疗作用。抗Aβ抗体滴度增加，脑内Aβ（可溶性和不溶性）和血清Aβ水平降低。由于在圈养组中IgG1 / IgG2a的值> 1，因此通过Aβ稻进行的免疫可能会引起非炎症性Th2反应。我们还发现，通过Y迷宫测试评估，Aβ疫苗可改善记忆力。在A-beta喂养组中，Y迷宫测试中的手臂进入次数低于对照组。这些结果表明，新型可食用疫苗Aβ水稻可能对AD有治疗作用。

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