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首页> 外文期刊>Vaccine >Antibody responses to pneumococcal and haemophilus vaccinations in patients with B-cell chronic lymphocytic leukaemia
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Antibody responses to pneumococcal and haemophilus vaccinations in patients with B-cell chronic lymphocytic leukaemia

机译：B细胞慢性淋巴细胞性白血病患者对肺炎球菌和嗜血杆菌疫苗的抗体反应

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摘要

Although vaccination against Streptococcus pneumoniae (S. penumoniae) and Haemophilus influenzae type b (Hib) is recommended for immunocompromised patients, such as patients with B-cell chronic lymphocytic leukaemia (B-CLL), its protective effect is questionable. We studied antibody responses to pneumococcal polysaccharide vaccine (Pneumovax-23(R)) and to conjugated H. influenzae type b-vaccine (Act-Hib(R)) in 25 patients with B-CLL. After vaccination, the number of patients with antibody levels in the protective range against pneumococcal serotypes and H. influenzae b increased from 9 (38%) to 12 (50%), of 24 patients and from 8 (35%) to 11 (48%) of 23 patients, respectively. The patients with adequate antibody response to Pneumovax-23(R) and Act-Hib(R) had significantly less advanced stages of B-CLL, higher gammaglobulin levels, total IgG-levels and IgG-subclasses 2 and 4 levels, and lower levels of soluble CD23. Consequently, vaccination with these vaccines should be given as soon as the diagnosis of B-CLL is made early in the course of the disease with determination of post-vaccination antibody levels.
机译：尽管对于免疫功能低下的患者（例如B细胞慢性淋巴细胞性白血病（B-CLL）患者），建议对肺炎链球菌（S. penumoniae）和b型流感嗜血杆菌（Hib）进行疫苗接种，但其保护作用值得怀疑。我们在25名B-CLL患者中研究了对肺炎球菌多糖疫苗（Pneumovax-23（R））和缀合的流感嗜血杆菌b型疫苗（Act-Hib（R））的抗体反应。接种疫苗后，抗体水平在针对肺炎球菌血清型和流感嗜血杆菌的保护范围内的患者人数从9（38％）增加到12（50％），从24名患者增加到从8（35％）到11（48） ％）分别为23名患者。对Pneumovax-23（R）和Act-Hib（R）有足够抗体应答的患者的B-CLL晚期阶段明显减少，丙种球蛋白水平较高，总IgG水平以及IgG亚类2和4的水平，以及较低的水平可溶性CD23。因此，应在疾病过程的早期诊断出B-CLL，并确定疫苗接种后的抗体水平，以便立即接种这些疫苗。

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