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首页> 外文期刊>Vaccine >Endemic infection of a cat colony with a feline calicivirus closelyrelated to an isolate used in live attenuated vaccines
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Endemic infection of a cat colony with a feline calicivirus closelyrelated to an isolate used in live attenuated vaccines

机译：猫杯状病毒对猫群的地方性感染与减毒活疫苗中使用的分离株密切相关

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We have typed three feline calicivirus (FCV) isolates obtained over a 5-month-period from an endemically infected cat colony. Sequence analysis from variable region E of the capsid gene from these isolates strongly suggests they are minor variants of a single FCV strain. and that this strain is closely related to the one used in many live-attenuated FCV vaccines. Such a vaccine was last used approximately 2 months before the first of the isolates in this study was obtained. Sequence differences between the colony isolate' and the vaccine virus suggest that the colony virus has evolved from the vaccine virus and was persisting in the colony. The extent to which vaccine virus may contribute to the continued high prevalence of FCV needs to be deter-mined.
机译：我们分型了三个猫科杯状病毒（FCV）分离株，这些分离株在5个月内从地方性感染的猫群中获得。来自这些分离物的衣壳基因的可变区E的序列分析强烈表明，它们是单个FCV株的较小变体。并且该菌株与许多减毒活的FCV疫苗中使用的菌株密切相关。在获得本研究中的第一个分离株之前，最后使用这种疫苗大约2个月。菌落分离物和疫苗病毒之间的序列差异表明，菌落病毒已经从疫苗病毒进化而来并在菌落中持续存在。需要确定疫苗病毒可能导致FCV持续高流行的程度。

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