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首页> 外文期刊>Vaccine >Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel
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Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel

机译：美军人员炭疽疫苗吸附引起的血清IgG抗体对炭疽芽孢杆菌保护性抗原（PA）的反应

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摘要

The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83mug/mL). Three doses elicited a GMC of 59.92mug/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44mug/mL and 67.9% and the sixth of 276.95mug/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.
机译：研究了用吸附了美国许可的炭疽疫苗免疫了3、4和6次的美国军人存储的血清中IgG抗PA的血清转化率和几何平均浓度（GMC）。通过ELISA测量抗PA IgG浓度。所有246种疫苗接种者的免疫前抗PA IgG含量均较低，但可检测到（GMC 1.83ug / mL）。三剂引起的GMC为59.92mug / mL，血清转换率为85.3％，四剂引起的GMC为157.44mug / mL和67.9％，第六剂为276.95mug / mL和45.5％。与免疫前水平相比，第四剂量引起100％的血清转化。这些结果应有助于比较不同的免疫方案和新疫苗。

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