Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

Fletcher HA; Pathan AA; Berthoud TK; Dunachie SJ; Whelan KT; Alder NC; Sander CR; Hill AV; McShane H

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Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

机译：用MVA85A加强BCG疫苗接种可下调免疫调节细胞因子TGF-beta1。

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In clinical trials recombinant-modified vaccinia virus Ankara expressing the Mycobacterium tuberculosis antigen 85A (MVA85A) induces approximately 10 times more effector T cells than any other recombinant MVA vaccine. We have found that in BCG primed subjects MVA85A vaccination reduces transforming growth factor beta 1 (TGF-beta1) mRNA in peripheral blood lymphocytes and reduces TGF-beta1 protein in the serum, but increases IFN-gamma ELISPOT responses to the recall antigen SK/SD. TGF-beta1 is essential for the generation of regulatory T cells and we see a correlation across vaccinees between CD4+CD25hiFoxP3+ cells and TGF-beta1 serum levels. This apparent ability to counteract regulatory T cell effects suggests a potential use of MVA85A as an adjuvant for less immunogenic vaccines.

机译：在临床试验中，表达结核分枝杆菌抗原85A（MVA85A）的重组修饰痘苗病毒安卡拉（Ankara）诱导的效应T细胞比任何其他重组MVA疫苗多约10倍。我们发现在BCG引发的受试者中，MVA85A疫苗接种可降低外周血淋巴细胞中的转化生长因子β1（TGF-beta1）mRNA，并降低血清中的TGF-beta1蛋白，但会增加对召回抗原SK / SD的IFN-γELISPOT反应。。 TGF-beta1对于产生调节性T细胞至关重要，我们看到CD4 + CD25hiFoxP3 +细胞与TGF-beta1血清水平之间跨疫苗的相关性。这种明显的抵抗调节性T细胞效应的能力表明，MVA85A作为免疫原性较低的疫苗佐剂的潜在用途。

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《Vaccine》 |2008年第41期|共7页
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Fletcher HA; Pathan AA; Berthoud TK; Dunachie SJ; Whelan KT; Alder NC; Sander CR; Hill AV; McShane H;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. [J] . Fletcher HA, Pathan AA, Berthoud TK, Vaccine . 2008,第41期

机译：用MVA85A加强BCG疫苗接种可下调免疫调节细胞因子TGF-beta1。
2. BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi. [J] . Lalor MK, Floyd S, Gorak Stolinska P, The Journal of Infectious Diseases . 2011,第7期

机译：英国和马拉维的婴儿BCG疫苗接种后，BCG疫苗接种诱导了不同的细胞因子谱。
3. BCG Vaccination Induces Different Cytokine Profiles Following Infant BCG Vaccination in the UK and Malawi [J] . Maeve K. Lalor, Sian Floyd, Patricia Gorak-Stolinska, Journal of Infectious Diseases . 2011,第7期

机译：英国和马拉维的婴儿BCG疫苗接种后，BCG疫苗接种可诱导不同的细胞因子谱
4. Sustained Release of Functional Interleukin-10 Encapsulated within Poly (lactic acid)-b-Poly (ethylene glycol) Nanoparticles Down-regulates Cytokines in Mouse Macrophages Exposed to Chlamydia trachomatis [C] . Skyla Duncan, Saurabh Dixit, Rajnish Sahu, Annual TechConnect World Innovation Conference Expo;Annual Nanotech Conference Expo;National SBIR/STTR Conference . 2017

机译：封装在聚（乳酸）-b-聚（乙二醇）纳米颗粒中的功能性白介素10的持续释放下调暴露于沙眼衣原体的小鼠巨噬细胞中的细胞因子。
5. Immunology of BCG vaccination in mice: Implications for tuberculosis vaccination and for the use of BCG as a recombinant vaccine vector. [D] . Power, Carl Andrew. 2000

机译：小鼠BCG疫苗接种的免疫学：对结核疫苗的接种以及BCG作为重组疫苗载体的用途。
6. Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-β1 [O] . Helen A. Fletcher, Ansar A. Pathan, Tamara K. Berthoud, -1

机译：用MVA85A加强BCG疫苗接种可下调免疫调节细胞因子TGF-β1
7. Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. [O] . Fletcher, HA, Pathan, AA, Berthoud, TK, 2008

机译：用MVA85A加强BCG疫苗接种可下调免疫调节细胞因子TGF-beta1。

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

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