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首页> 外文期刊>Vaccine >Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serumantibody response to antigen co-administered by the intranasal route
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Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serumantibody response to antigen co-administered by the intranasal route

机译：Fragilysin，来自脆弱拟杆菌的肠毒素，可增强对鼻内途径共同施用抗原的血清抗体反应

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摘要

Fragilysin, an extracellular zinc metalloprotease produced by enterotoxigenic strains of the anaerobic bacterium Bacteroides fragilis, disrupts the paracellular barrier by cleavage of the intercellular proteins between epithelial cells resulting in fluid secretion. Intranasal immunization of mice with fragilysin and co-administered ovalbumin (Ova) resulted in an Ova-specific serum IgG response that was over 18 000-fold higher than Ova alone, as well as detectable levels of serum IgA. Serum IgG titers were comparable with those seen when whole cholera toxin was used as the adjuvant, although the responses obtained with fragilysin showed more variability between mice, Metalloproteases to which fragilysin is structurally related were ineffective as mucosal adjuvants. Our results and similar studies with enterotoxins that affect the paracellular barrier suggest that alteration of mucosal permeability may Flay an important role in the mechanisms of adjuvanticity.
机译：Fragilysin是一种由厌氧细菌脆弱拟杆菌（Bacteroides fragilis）的产毒菌株产生的细胞外锌金属蛋白酶，它通过切割上皮细胞之间的细胞间蛋白而破坏细胞旁屏障，从而导致液体分泌。用fragilysin和卵白蛋白（Ova）共同给药对小鼠进行鼻内免疫，产生的Ova特异性血清IgG反应比单独的Ova高1.8万倍，并且血清IgA水平可检测。血清IgG滴度与使用全霍乱毒素作为佐剂时可观察到的IgG滴度相当，尽管用fragilysin获得的反应在小鼠之间显示出更大的变异性，与fragilysin结构相关的金属蛋白酶作为粘膜佐剂无效。我们的结果以及对影响肠旁细胞屏障的肠毒素的类似研究表明，粘膜通透性的改变可能使Flay在佐剂形成机制中发挥重要作用。

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