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首页> 外文期刊>Vaccine >Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine
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Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine

机译：接种C型血清群脑膜炎球菌结合疫苗后3-6岁儿童和青少年血清杀菌活性的调查

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Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at: a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age <6 years (85.9%), followed by those between 6 and 10 years (62.2%). This percentage was considerably lower in adolescents vaccinated at an age >10 years (37.8%) (p < 0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection.
机译：2001年在希腊引入了C群脑膜炎球菌结合疫苗，尽管2004年未记录C群脑膜炎球菌疾病病例，但自2005年以来一直稳定增长。在这项研究中，评估了269名接种疫苗的儿童血清中的血清杀菌活性。 ：接种后平均约5年。在大多数6岁以下接种疫苗的儿童中观察到非保护性抗体滴度（85.9％），其次是6至10岁的儿童（62.2％）。在接种10岁以上的青少年中，这一百分比要低得多（37.8％）（p <0.01）。抗血清群C的血清IgG抗体的几何平均浓度显示出相似的变化。结果表明血清杀菌抗体滴度与疫苗接种年龄显着相关。大多数儿童在婴儿期和童年免疫后几年都没有保护性抗体滴度，而大多数青少年则保持持续的保护。

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