IgM, not IgG, a key for HIV vaccine

Yang QE

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IgM, not IgG, a key for HIV vaccine

机译：IgM，而不是IgG，是HIV疫苗的关键

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Although HIV infections induce a very strong humoral immune reaction with various neutralization activities and a well-defined cellular immunity, HIV vaccine development based on traditional approaches failed. The fact that neither specific antibodies nor activated CD8(+) cytotoxicity T-cells could provide primary protection in high risk populations raises the question concerning whether a specific vaccine is feasible. While the immune system as an intact defense system against HIV is ineffective or may even enhance the virus spread, a distinct small part of the system plays important role in delaying the progress of the disease. After carefully dissecting the different immune reactions against the virus, a new HIV vaccine strategy is indicated.

机译：尽管HIV感染会引起强烈的体液免疫反应，并具有各种中和活性和明确的细胞免疫性，但基于传统方法的HIV疫苗开发却失败了。特异性抗体或活化的CD8（+）细胞毒性T细胞均不能在高风险人群中提供主要保护这一事实提出了有关特定疫苗是否可行的问题。免疫系统作为完整的针对HIV的防御系统无效，甚至可能会增强病毒的传播，但该系统的一小部分在延缓疾病的进展方面起着重要作用。在仔细剖析了针对该病毒的不同免疫反应后，表明了一种新的HIV疫苗策略。

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《Vaccine》 |2009年第9期|共2页
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Yang QE;
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中图分类卫生标准、卫生检查、医药管理;
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机译：输注异体免疫IgG和Igm对猴的实验性输血反应，溶血，凝血和肾脏效应

IgM, not IgG, a key for HIV vaccine

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