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首页> 外文期刊>Vaccine >Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3-months post vaccination
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Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV-PCV2-SIV clinical infection model 2-3-months post vaccination

机译：接种后2到3个月使用混合PRRSV-PCV2-SIV临床感染模型对商业一剂和两剂PCV2疫苗的疗效比较

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摘要

The study objectives were to compare the duration of immunity of commercially available, one and two dose, killed porcine circovirus type 2 (PCV2) vaccines. Sixty, 3.5-week-old pigs were randomly divided into six treatment groups: one dose vaccines (FDAH-1, BIVI-1), two dose vaccines (Intervet-2, FDAH-2), and non-vaccinated negative and positive controls. Tissue homogenate challenge was conducted 63 (two doses) or 84 (one dose) days post vaccination. Viremia was reduced by 78.5% in pigs vaccinated with one dose and by 97.1% in pigs vaccinated with two dose products and overall microscopic lymphoid lesions were reduced by 78.7% and 81.8%, respectively.
机译：研究目的是比较市售的一剂和两剂灭活的猪圆环病毒2型（PCV2）疫苗的免疫持续时间。将60只3.5周龄的猪随机分为六个治疗组：一剂疫苗（FDAH-1，BIVI-1），两剂疫苗（Intervet-2，FDAH-2）以及未接种疫苗的阴性和阳性对照。接种后63天（两剂）或84天（一剂）进行组织匀浆攻击。接种一剂疫苗的猪的病毒血症降低了78.5％，接种了两剂产品的猪的病毒血症降低了97.1％，总体微观淋巴样病变分别降低了78.7％和81.8％。

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