...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Considerations and procedures in the derivation of ATSDR minimal risk levels
【24h】

Considerations and procedures in the derivation of ATSDR minimal risk levels

机译：得出ATSDR最低风险水平的注意事项和程序

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Minimal risk levels (MRLs) are health-based guidance values derived for individual substances by conducting a thorough review of the literature, identifying appropriate target organs of response, and identifying a dose level where a no adverse effect or the lowest adverse effect level is seen. This level is then evaluated for uncertainty in the data base and for other extenuating factors and subsequently adjusted with uncertainty or modifying factors. The resulting calculation yields the MRL that is defined as an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure. Typically, MRLs are derived for different durations of exposure (acute, intermediate, chronic) and for different routes of exposure (oral, inhalation). The MRLs serve as useful reference values in evaluating human health from exposure to substances found at hazardous waste sites. Because of numerous requests of various programs, recent work has focused on expanding the applicability of MRLs to other situations and routes of exposure (dermal, food supply, intramuscular) beyond the traditional oral and inhalation exposure routes at waste sites. Results of work, in conjunction with the Agency for Toxic Substances and Disease Registry's computational toxicology laboratory, shows that the use of computational methods, such as physiologically based pharmacokinetic modeling, may allow the MRL process to be adapted to unique durations and routes of exposure such as intramuscular injections.
机译：最低风险水平（MRLs）是通过对文献进行全面审查，确定适当的反应靶器官并确定无不良反应或最低不良反应水平的剂量水平而得出的针对每种物质的基于健康的指导值。然后评估该级别的数据库中不确定性和其他衰减因素，然后使用不确定性或修改因素进行调整。结果计算得出的最大残留限量（MRL）被定义为在规定的暴露持续时间内，人体每天可能暴露于有害物质的估计值，而该有害物质可能没有明显的不良非癌症健康影响。通常，MRL是针对不同的暴露时间（急性，中度，慢性）和不同的暴露途径（口服，吸入）得出的。在评估有害废物场所发现的物质对人类健康的影响时，最大残留限量是有用的参考值。由于各种计划的众多要求，最近的工作集中在扩大MRL的适用范围，使其超越废物场所传统的口服和吸入暴露途径，从而适用于其他情况和暴露途径（皮肤，食物供应，肌肉内）。工作结果与有毒物质和疾病登记局的计算毒理学实验室的结合表明，使用诸如基于生理学的药代动力学模型等计算方法，可以使MRL过程适应独特的暴露时间和途径。作为肌肉注射。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号