Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

Takasaki T; Yabe S; Nerome R; Ito M; Yamada KI; Kurane I

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Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

机译：灭活的日本脑炎疫苗对小鼠致命的西尼罗河病毒感染的部分保护作用

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The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the immunized mice were protected. When mice were intraperitoneally challenged, the immunized mice were protected at higher immunization levels. Cross-reactive neutralizing antibodies to WNV were induced by immunization with JE vaccine; however, the levels were much lower than those to JEV. These results indicate that the currently available mouse brain-derived inactivated JE vaccine can induce partial protective immunity to WNV in mice.

机译：使用鼠模型检查了小鼠脑源灭活的日本脑炎（JE）疫苗对西尼罗河病毒（WNV）感染的影响。用JE疫苗免疫小鼠两次，并用致死剂量的WNV攻击。当用WNV颅内攻击小鼠时，没有免疫小鼠受到保护。当小鼠腹膜内攻击时，以更高的免疫水平保护免疫的小鼠。用JE疫苗免疫可诱导产生针对WNV的交叉反应中和抗体。但是，这一水平远低于JEV的水平。这些结果表明，当前可用的小鼠脑源灭活的JE疫苗可以在小鼠中诱导对WNV的部分保护性免疫。

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来源
《Vaccine》 |2003年第31期|共5页
作者
Takasaki T; Yabe S; Nerome R; Ito M; Yamada KI; Kurane I;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
West nile virus; Japanese encephalitis virus; Flaviviridae; Vaccine; Strains;

机译：西尼罗河病毒;日本脑炎病毒;黄病毒科;疫苗;毒株;

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1. Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice [J] . Takasaki T, Yabe S, Nerome R, Vaccine . 2003,第31期

机译：灭活的日本脑炎疫苗对小鼠致命的西尼罗河病毒感染的部分保护作用
2. Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: effects of WN virus NS1 antibodies induced by inactivated WN vaccine. [J] . Kitai Y., Kondo T., Konishi E. Journal of Virological Methods . 2011,第1期

机译：基于非结构蛋白1（NS1）抗体的分析方法，用于将西尼罗河（WN）病毒与马的日本脑炎病毒感染区分开：WN病毒灭活WN疫苗诱导的NS1抗体的作用。
3. Specific antibody responses to West Nile virus infections in horses preimmunized with inactivated Japanese encephalitis vaccine: evaluation of blocking enzyme-linked immunosorbent assay and complement-dependent cytotoxicity assay. [J] . Kitai Y, Shirafuji H, Kanehira K, Vector borne and zoonotic diseases . 2011,第8期

机译：用灭活的日本脑炎疫苗预免疫的马对西尼罗河病毒感染的特异性抗体反应：评估封闭酶联免疫吸附测定和补体依赖性细胞毒性测定。
4. Comparative Epidemiologies of Eastern Equine Encephalitis Virus, Western Equine Encephalitis Virus, Venezuelan Equine Encephalitis Virus, and West Nile Virus [C] . Charles H. Calisher Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

机译：东部大雄脑炎病毒，西马脑炎病毒，委内瑞拉脑脑炎病毒和西尼罗河病毒的比较流行病学
5. Risk factors for encephalitis and death from West Nile virus infection: An analysis of hospitalized cases in Houston, Texas from 2002–2008 [D] . Wright, John Allen 2009

机译：西尼罗河病毒感染导致脑炎和死亡的危险因素：德克萨斯州休斯敦市2002-2008年住院病例分析
6. An Inactivated Cell Culture Japanese Encephalitis Vaccine (JE-ADVAX) Formulated with Delta Inulin Adjuvant Provides Robust Heterologous Protection against West Nile Encephalitis via Cross-Protective Memory B Cells and Neutralizing Antibody [O] . Nikolai Petrovsky, Maximilian Larena, Venkatraman Siddharthan, 2013

机译：配制有Delta菊粉佐剂的灭活细胞培养日本脑炎疫苗（JE-ADVAX）可通过交叉保护性B细胞和中和抗体对西尼罗河脑炎提供强大的异源保护。
7. Vero cell-derived inactivated West Nile (WN) vaccine induces protective immunity against lethal WN virus infection in mice and shows a facilitated neutralizing antibody response in mice previously immunized with Japanese encephalitis vaccine [O] . Lim Chang-Kweng, Takasaki Tomohiko, Kotaki Akira, 2008

机译：Vero细胞衍生的灭活西尼罗河（WN）疫苗在小鼠中诱导针对致命WN病毒感染的保护性免疫，并在先前用日本脑炎疫苗免疫的小鼠中显示出促进的中和抗体反应
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

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