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首页> 外文期刊>Vaccine >Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge
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Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge

机译：用含有马传染性贫血病毒ELA-A1限制性CTL表位的脂肽免疫的ELA-A1马对病毒攻击的反应

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摘要

Lipopeptide containing an ELA-A1-restricted cytotoxic T lymphocyte (CTL) epitope from the envelope surface unit (SU) protein of the EIAV(WSU5) strain was used to immunize three horses having the ELA-A1 haplotype. Peptide-specific ELA-A1-restricted CTL were induced in all three horses, although these were present transiently in PBMC. These horses were further immunized with lipopeptide containing the corresponding CTL epitope from the EIAV(PV) strain. Then, the three immunized horses and three non-immunized horses were challenged by intravenous inoculation with 300 TCID50 EIAV(PV). All horses developed cell free viremia, fever and thrombocytopenia. However, there was a statistically lower fever and thrombocytopenia severity score in the immunized group. Shorter duration of plasma viral load in two of the three immunized horses likely explains the less severe clinical disease in this group. Results indicate that lipopeptide immunization had a protective effect against development of clinical disease following virus challenge.
机译：包含来自EIAV（WSU5）株包膜表面单位（SU）蛋白的ELA-A1限制性细胞毒性T淋巴细胞（CTL）表位的脂肽用于免疫三只具有ELA-A1单倍型的马。尽管在PBMC中瞬时存在肽特异性ELA-A1限制性CTL，所有三匹马均被诱导。这些马进一步用含有来自EIAV（PV）株的相应CTL表位的脂肽免疫。然后，通过静脉接种300 TCID50 EIAV（PV）攻击三只免疫的马和三只未免疫的马。所有马匹均出现无细胞病毒血症，发烧和血小板减少症。但是，免疫组的发烧和血小板减少症严重程度评分在统计学上较低。在三只接受免疫的马中的两匹中，血浆病毒载量的持续时间较短可能解释了该组中较轻的临床疾病。结果表明脂肽免疫具有抗病毒攻击后临床疾病发展的保护作用。

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