Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix (TM))

Alcon VL; Foldvari M; Snider M; Willson P; Gomis S; Hecker R; Babiuk

首页> 外文期刊>Vaccine >Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix (TM))

【24h】

Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix (TM))

机译：在基于脂质的递送系统（Biphasix（TM））中配制的CpG寡脱氧核苷酸免疫后，诱导猪的保护性免疫

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A large number of studies demonstrated the immumostimulatory effects of CpG oligonucleotides (ODN), particularly in mice. In the present study, we evaluated the ability of lipid-based delivery systems to enhance the adjuvant effect of CpG-ODN and protect against infection in a porcine pleuropneumonia model. Increased levels of OmlA-specific antibody were detected in animals immunised with OmlA and CpG-ODN formulated in the delivery system Biphasix(TM)-vaccine targeting adjuvant (VTA), compared to pigs immunised with VTA without CpG-ODN or CpG-ODN alone. In addition, the responses induced by VTA/CpG formulation were similar to those induced by the commercial adjuvant VSA; however, VTA formulations caused significantly less tissue damage than VSA.

机译：大量研究表明，CpG寡核苷酸（ODN）具有免疫刺激作用，尤其是在小鼠中。在本研究中，我们评估了基于脂质的递送系统在猪胸膜肺炎模型中增强CpG-ODN佐剂作用和预防感染的能力。与用不含CpG-ODN或CpG-ODN的VTA免疫的猪相比，在用BiphasixTM-疫苗靶向佐剂（VTA）配制的OmlA和CpG-ODN免疫的动物中检测到OmlA特异性抗体的水平增加。此外，VTA / CpG制剂诱导的应答与市售佐剂VSA诱导的应答相似。但是，VTA制剂比VSA引起的组织损伤明显更少。

著录项

来源
《Vaccine》 |2003年第18期|共4页
作者
Alcon VL; Foldvari M; Snider M; Willson P; Gomis S; Hecker R; Babiuk;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Lipid-based delivery system; Cpg-odn; Actinobacillus pleuropneumoniae; Actinobacillus-pleuropneumoniae; Dna; Liposomes; Antigen; Cells;

机译：基于脂质的递送系统;Cpg-odn;胸膜肺炎放线杆菌;胸膜肺炎放线杆菌;Dna;脂质体;抗原;细胞;

相似文献

外文文献
中文文献
专利

1. Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix (TM)) [J] . Alcon VL, Foldvari M, Snider M, Vaccine . 2003,第17a18期

机译：在基于脂质的递送系统（Biphasix（TM））中配制的CpG寡脱氧核苷酸免疫后，诱导猪的保护性免疫
2. Induction of Systemic TH1-Like Innate Immunity in Normal Volunteers Following Subcutaneous but Not Intravenous Administration of CPG 7909, a Synthetic B-Class CpG Oligodeoxynucleotide TLR9 Agonist. [J] . Krieg AM, Wittpoth M, Davis HL Journal of immunotherapy . 2004,第6期

机译：皮下但非静脉内施用CPG 7909（一种合成的B类CpG寡脱氧核苷酸TLR9激动剂）后，在正常志愿者中诱导全身性TH1类似先天免疫。
3. Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides [J] . Agallou Maria, Pantazi Eleni, Tsiftsaki Elisavet, Molecular Immunology . 2018,第期

机译：用树突式细胞脉冲的树突式细胞介导的实验性内脏Leishmaniaisis的保护性细胞免疫反应诱导与Leishmania肾小管伸长因子-2和Cpg oligodeNynatorates的N-末端结构核苷酸介导
4. DOES THE MODE OF DELIVERY FOR CpG OLIGODEOXYNUCLEOTIDE PLAY ANY ROLE IN ITS ADJUVANTICITY? [C] . Manish Diwan, Mohsen Tafaghodi, John Samuel Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：CpG寡聚脱氧核糖核酸的递送模式是否在其辅助性中发挥任何作用？
5. Evaluation of lipid-based delivery systems for induction of mucosal and systemic immune responses: Effect of CpG motifs [D] . Alcon, Valeria L. 2004

机译：基于脂质的传递系统对粘膜和全身免疫反应的诱导评价：CpG序列的影响
6. Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin [O] . Chunmei Cheng, Ilham Bettahi, Maria I. Cruz-Fisher, -1

机译：利用CpG寡核苷酸的主要外膜蛋白接种促抗衣原体粉碎蛋白母膜诱导保护性免疫诱导霍乱毒素的无毒B亚基
7. CpG oligodeoxynucleotides promote the host protective response against infection with Cryptococcus neoformans through induction of interferon-gamma production by CD4+ T cells [O] . Miyagi, K, Kawakami, K, Kinjo, Y, 2005

机译：CpG寡脱氧核苷酸通过诱导CD4 + T细胞产生γ干扰素来促进宿主抵抗新隐球菌感染
8. Rapid Induction of Protective Immunity Against Biothreat Agents Using CPG-Based Oligonucleotides [R] . Klinman, D. M. 2003

机译：使用基于CpG的寡核苷酸快速诱导对生物威胁剂的保护性免疫

Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix (TM))

摘要

著录项

相似文献

相关主题

期刊订阅