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首页> 外文期刊>Vaccine >Report of the Meningitis Program of the International Scientific Working Group on TBE Serological screening of patients with viral CNS-infection of unknown etiology in search of undiagnosed TBE cases
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Report of the Meningitis Program of the International Scientific Working Group on TBE Serological screening of patients with viral CNS-infection of unknown etiology in search of undiagnosed TBE cases

机译：国际科学工作组脑膜炎计划的报告：对病毒性中枢神经系统感染的病因进行血清学筛查，病因不明，以寻找未诊断的TBI病例

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摘要

The endemicity of tick-borne encephalitis (TBE) in Europe is changing. Potential undetected or emerging TBEV foci and the risk of underdiagnosis due to a low awareness among the medical community form the background of this retrospective multicenter follow-up study. We investigated the possibility of undiagnosed TBE cases among patients with presumed viral central nervous system (CNS)-infection of unknown etiology. Eight centers in four European countries provided sera and/or cerebrospinal fluid (CSF) samples from 233 individuals. The samples were screened with a commercial TBEV ELISA test system (IgM and IgG). Positive or borderline samples were re-evaluated at the Institute of Virology in Vienna by an in-house ELISA test and a neutralization test (NT). Two previously undiagnosed Swedish TBE patients were verified. Three additional individuals from Swedish centers were IgG ELISA and NT positive. No NT positive individuals were found from France, Belgium or The Netherlands. Nineteen individuals were found lgG TBE ELISA positive, but negative in NT, indicating unspecific reactivity. At least four of those patients were vaccinated against yellow fever. The probable reason for the reactivity seen in these individuals is the well-known cross-reactivity existing among flaviviruses.
机译：在欧洲，tick传脑炎（TBE）的流行正在发生变化。这项回顾性多中心随访研究的背景是，潜在的未发现或正在出现的TBEV病灶以及由于医学界认识不足而导致诊断不足的风险。我们调查了病因不明的病毒性中枢神经系统（CNS）感染患者中未被诊断的TBE病例的可能性。欧洲四个国家的八个中心提供了233个人的血清和/或脑脊液（CSF）样本。用商业TBEV ELISA测试系统（IgM和IgG）筛选样品。阳性或临界样品在维也纳病毒研究所通过内部ELISA测试和中和测试（NT）进行了重新评估。两名先前未诊断的瑞典TBE患者得到了证实。来自瑞典中心的另外三个人是IgG ELISA和NT阳性。从法国，比利时或荷兰未发现任何NT阳性个体。发现19个个体的IgG TBE ELISA呈阳性，但在NT中呈阴性，表明非特异性反应性。这些患者中至少有四名接种了黄热病疫苗。在这些个体中看到反应的可能原因是黄病毒之间存在众所周知的交叉反应。

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