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Role of L-lysine HCl in immunopotentiation towards development of suitable tuberculosis vaccination

机译：盐酸L-赖氨酸在免疫增强作用中的作用，适用于适当的结核病疫苗接种

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L-Lysine HCl is being proposed to be a possible biocompatible adjuvant to enhance immune response by virtue of its probable non-specific bridging action and cellular proliferation properties. This proposal has been tried to be substantiated by carrying out experimentation where L-lysine HCl has been used as an adjuvant (various groups based on mode of application and frequency of booster dose were designed) in tuberculosis vaccination experiments with heat killed Mycobacterium tuberculosis (MTB) and Bacille Calmette Guerin (BCG). Antibody titre has been followed in all the experiments as a measure of immune response. Amongst the various groups designed, group 1A (L-lysine HCl was given at a separate site as that of the antigen; lysine booster was given to this group intermittently, i.e. lysine given on 0th, 7th, 14th, 21st days of immunization) came out as the stand-alone leader. This mode and frequency of application was then compared with a group which received a standard adjuvant, viz. alhydrogel. Results were obtained which showed the following order in terms of decreasing antibody titre: alhydrogel group > lysine group > control group. Considering the biocompatible nature of lysine in comparison with the reportedly hazardous nature of alum adjuvants, we propose L-lysine HCl as a probable adjuvant in vaccination.
机译：由于其可能的非特异性桥接作用和细胞增殖特性，L-赖氨酸盐酸盐被认为是可能的增强免疫应答的生物相容性佐剂。通过在热灭活的结核分枝杆菌（MTB）的结核病疫苗接种实验中使用L-赖氨酸盐酸盐作为佐剂（设计了基于应用模式和加强剂量的频率的各种基团）的实验，试图证实该建议的有效性。 ）和Bacille Calmette Guerin（BCG）。在所有实验中都遵循抗体效价作为免疫应答的量度。在设计的各个组中，第1A组（在L-赖氨酸的HCl与抗原的一个单独的位置给予;赖氨酸加强剂间歇给予该组，即在免疫的第0、7、14、21天给予赖氨酸）成为独立领导者。然后将这种施用方式和频率与接受标准佐剂的一组进行比较。水凝胶。获得的结果按照降低抗体滴度的顺序显示以下顺序：水凝胶组>赖氨酸组>对照组。考虑到赖氨酸的生物相容性与据报道的明矾佐剂的危险性相比，我们建议使用L-赖氨酸盐酸盐作为疫苗接种中的佐剂。

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