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Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity

机译:Pentraxin 3,一种参与先天免疫的非冗余可溶性模式识别受体

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摘要

Pentraxin 3 (PTX3) is the first long pentraxin identified. Long pentraxins consist of a C-terminal pentraxin domain, which has sequence similarity to C-reactive protein (CRP) and serum amyloid P (SAP) component (the classic short pentraxins), and of an unrelated N-terminal portion. PTX3 is made by diverse cell types, most prominently endothelial cells, macrophages and dendritic cells, in response to primary inflammatory signals (e.g. interleukin-1 (IL-1), turnout necrosis factor (TNF), lipopolysaccharide (LPS)). It binds diverse ligands, including microbial moieties, Clq and apoptotic cells. Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
机译:Pentraxin 3(PTX3)是第一个鉴定出的长戊型毒素。长的五肽毒素由一个C末端的五肽毒素域组成,该域与C反应蛋白(CRP)和血清淀粉样蛋白P(SAP)成分(经典的短五味子毒素)具有序列相似性,并且具有一个不相关的N末端部分。 PTX3是由多种细胞类型制成的,主要响应内皮细胞,巨噬细胞和树突状细胞对原发性炎症信号(例如白介素-1(IL-1),发生率坏死因子(TNF),脂多糖(LPS))的响应。它结合各种配体,包括微生物部分,Clq和凋亡细胞。有证据表明,PTX3在调节对病原体的固有抗性,炎症反应,可能清除自身成分和女性生育能力中起作用。

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