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Efficient vaccine against the virus causing a lethal disease in cultured Cyprinus carpio

机译：针对在养殖鲤鱼中引起致命性疾病的病毒的高效疫苗

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We have isolated a virus, which causes a mortal disease in cultured ornamental Koi and Common carps (Cyprinus carpio) in many countries worldwide. This unclassified virus, which causes nephritis and gill necrosis, and so has been given the name carp nephritis and gill necrosis virus (CNGV), has a morphology resembling the herpes virus, but bears a genomic DNA of ca 250-300 kbp. So far, both others and we have been unable to find CNGV-DNA sequences possessing a significant similarity to known DNA viruses. The virus induces a lethal disease when water temperature ranges between 18 and 25 degreesC (permissive temperature). In this report, we demonstrate that carps, exposed to the virus at 23 degreesC for 3-5 days and then transferred to the non-permissive temperature of 30 degreesC, became resistant to a challenged infection and their sera demonstrated a high level of virus-specific antibodies. We have isolated attenuated non-pathogenic viruses that render virus-vaccinated carps resistant to the disease. Furthermore, vaccinated fish developed high levels of antibodies against the virus. We suggest, therefore, that this attenuated virus could be used as a live vaccine for the eradication of the mortal disease afflicting Common and ornamental carp fisheries in many countries.
机译：我们已经分离出一种病毒，该病毒在全世界许多国家的人工养殖锦鲤和鲤鱼中引起致命性疾病。这种未分类的病毒会引起肾炎和g坏死，因此被称为鲤鱼肾炎和g坏死病毒（CNGV），其形态类似于疱疹病毒，但具有约250-300 kbp的基因组DNA。到目前为止，其他人和我们都无法找到与已知DNA病毒具有显着相似性的CNGV-DNA序列。当水温在18到25摄氏度（允许温度）之间时，病毒会导致致命的疾病。在这份报告中，我们证明了鲤鱼暴露于23摄氏度的病毒中3-5天，然后转移到30摄氏度的非许可温度下，能够抵抗感染的感染，其血清显示出高水平的病毒-特异性抗体。我们已经分离出减毒的非致病性病毒，使病毒接种的鲤鱼对该病具有抵抗力。此外，接种疫苗的鱼产生了高水平的抗病毒抗体。因此，我们建议，这种减毒病毒可以用作活疫苗，以根除许多国家困扰普通和观赏鲤鱼渔业的致命疾病。

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