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首页> 外文期刊>Vaccine >CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
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CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems

机译：CTLA-4阻断剂与异种DNA疫苗结合可增强T细胞反应，肿瘤免疫和动物和细胞模型系统中自身抗原的自身免疫

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Xenogeneic DNA vaccination can elicit tumor immunity through T cell and antibody-dependent effector mechanisms. Blockade of CTLA-4 engagement with B7 expressed on APCs has been shown to enhance T cell-dependent immunity. We investigated whether CTLA-4 blockade could increase T-cell responses and tumor immunity elicited by DNA vaccines. CTLA-4 blockade enhanced B 16 tumor rejection in mice immunized against the melanoma differentiation antigens tyrosinase-related protein 2 and gp100, and this effect was stronger when anti-CTLA-4 was administered with booster vaccinations. CTLA-4 blockade also increased the T-cell responses to prostate-specific membrane antigen (PSMA) when given with the second or third vaccination. Based on these pre-clinical studies, we suggest that anti-CTLA-4 should be tested with xenogeneic DNA vaccines against cancer and that special attention should be given to sequence and schedule of administration
机译：异种DNA疫苗接种可通过T细胞和抗体依赖性效应子机制引发肿瘤免疫。已经证明，CTLA-4与APC上表达的B7的结合可以增强T细胞依赖性免疫。我们调查了CTLA-4阻断是否可以增加DNA疫苗引起的T细胞应答和肿瘤免疫力。在针对黑色素瘤分化抗原酪氨酸酶相关蛋白2和gp100免疫的小鼠中，CTLA-4阻断增强了B 16肿瘤排斥反应，当抗CTLA-4配合加强疫苗接种时，这种作用更强。当第二次或第三次接种疫苗时，CTLA-4阻断也增加了T细胞对前列腺特异性膜抗原（PSMA）的反应。根据这些临床前研究，我们建议抗CTLA-4应该用抗癌的异种DNA疫苗进行测试，并且应该特别注意给药的顺序和时间表

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