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Role of the virology diagnosis laboratory in the surveillance of rubella virus Cuba 1988/2000

机译：病毒学诊断实验室在风疹病毒监测中的作用古巴1988/2000

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In Cuba, on the basis of Measles Elimination Program, the incidence of this disease decline, and was necessary to test rubella virus as a possible etiology agent that produce fever and rash illness. To reach this goal, Cuba developed rubella elimination strategies with integrated epidemiologic and laboratory surveillance. In the country, the vaccination program against rubella started in 1982 by vaccinating 12-14 years old females, with a special surveillance program with laboratory study of all suspected cases. Through 1988-2000, the Serology Diagnosis Laboratory in the Virology Branch of Pedro Kouri Institute had the responsibility to do the measles and rubella surveillance and play a key roll in the elimination strategies of these diseases. For confirmation of all suspected cases, 8566 serum samples with the suspected diagnosis of measles or rubella from different provinces in Cuba were studied in the laboratory using different techniques as haemagglutination inhibition test (HIA), ultra micro analytic assay (UMA); and in 1995 by the newly introduced IgM ELISA, which was used taken only one sample in the acute phase of the disease. These techniques allowed knowing that the annual number of reported rubella cases in the country decreased substantially after the implementation, in 1986, of the second vaccine policy, that of vaccinating women of childbearing age. However, in 1989, was detected an outbreak of rubella virus infection that had occurred in young adults male 15-19 age groups in Matanzas' province. The last three indigenous cases of this disease were confirmed by our laboratory in 1995, after national vaccine coverage over 95%.
机译：在古巴，根据消除麻疹计划，该疾病的发病率下降，因此有必要检测风疹病毒作为引起发烧和皮疹的可能病因。为了实现这一目标，古巴制定了具有综合流行病学和实验室监控的风疹消灭策略。在该国，针对风疹的疫苗接种计划始于1982年，当时为12至14岁的女性接种了疫苗，并通过一项针对所有可疑病例的实验室研究的特殊监视计划。在1988-2000年期间，佩德罗·库里研究所（Pedro Kouri Institute）病毒学分所的血清学诊断实验室负责进行麻疹和风疹的监测，并在消除这些疾病的策略中发挥了关键作用。为了确认所有可疑病例，在实验室中使用了不同的技术，如血凝抑制试验（HIA），超微分析（UMA），对来自古巴不同省的8566份疑似麻疹或风疹的血清样品进行了研究; 1995年通过新推出的IgM ELISA，仅在疾病的急性期使用了一个样本。这些技术使我们知道，在1986年实施第二项疫苗政策（为育龄妇女接种疫苗）之后，该国每年报告的风疹病例数量大大减少。但是，在1989年，在马坦萨斯省的15至19岁年龄段的年轻人中发现了风疹病毒感染的爆发。在国家疫苗覆盖率超过95％之后，我们的实验室在1995年确认了该疾病的最后三例本地病例。

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