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首页> 外文期刊>Vaccine >Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens
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Vaccine-induced host responses against very virulent Marek's disease virus infection in the lungs of chickens

机译：疫苗诱导的宿主应对鸡肺中极强的马立克氏病病毒感染

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摘要

The aim of this study was to investigate the kinetics of virus replication and cellular responses in the lungs following infection with Marek's disease virus (MDV) and/or vaccination with herpesvirus of turkey (HVT) via the respiratory route. Chickens vaccinated with HVT and challenged with MDV had a higher accumulation of MDV and HVT genomes in the lungs compared to the chickens that received HVT or MDV alone. This increase in virus load was associated with augmented expression of interferon (IFN)-gamma and interleukin (IL)-10, and increased T cell infiltration. These findings shed more light on the immunological events that occur in the lungs after vaccination or infection with MDV
机译：这项研究的目的是调查通过呼吸道感染马立克氏病病毒（MDV）和/或接种火鸡疱疹病毒（HVT）后，肺中病毒复制和细胞反应的动力学。与仅接受HVT或MDV的鸡相比，接种HVT并用MDV攻击的鸡在肺中的MDV和HVT基因组的积累更高。这种病毒载量的增加与干扰素（IFN）-γ和白介素（IL）-10的表达增加以及T细胞浸润增加有关。这些发现为接种疫苗或感染MDV后在肺部发生的免疫学事件提供了更多信息

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