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首页> 外文期刊>Vaccine >Antigenic and molecular heterogeneity in recent swine influenza A(H1N1)virus isolates with possible implications for vaccination policy
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Antigenic and molecular heterogeneity in recent swine influenza A(H1N1)virus isolates with possible implications for vaccination policy

机译：近期甲型H1N1流感病毒分离株的抗原和分子异质性可能对疫苗接种政策有影响

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摘要

In order to explore the occurrence of antigenic drift in swine influenza A(H1N1) viruses and the match between epidemic and vaccine strains. 26 virus isolates from outbreaks of respiratory disease among finishing pigs in the Netherlands in the 1995/1996 season and reference strains from earlier outbreaks were examined using serological and molecular methods. In contrast to swine H3N2 viruses, no significant antigenic drift was observed in swine H1N1 viruses isolated from the late 1980s up to 1996 inclusive. However. a marked antigenic and genetic heterogeneity in haemagglutination inhibition tests and nucleotide sequence analyses was detected among the 26 recent swine H1N1 virus strains. Interestingly, the observed antigenic and molecular variants were not randomly distributed over the farms. This finding indicates independent introductions of different swine H1N1 virus variants at the various farms of the study and points to a marked difference between the epidemiologies of human and swine influenza viruses. The observed heterogeneity may hamper the control of swine influenza by vaccination and indicates that the efficacy of current swine influenza vaccines requires re-evaluation and that the antigenic reactivity of swine influenza viruses should be monitored on a regular basis.
机译：为了探讨甲型H1N1猪流感病毒中抗原漂移的发生以及流行和疫苗株之间的匹配。在1995/1996年度，荷兰育成猪的呼吸道疾病暴发中分离出26种病毒，并使用血清学和分子方法对早期暴发的参考菌株进行了检测。与猪H3N2病毒相反，从1980年代后期至1996年末（含）的猪H1N1病毒中未观察到明显的抗原漂移。然而。在血凝抑制试验和核苷酸序列分析中，在26株最近的猪H1N1病毒株中检测到明显的抗原和遗传异质性。有趣的是，观察到的抗原和分子变异并非随机分布在农场中。这一发现表明在该研究的各个农场中独立引入了不同的猪H1N1病毒变种，并指出了人类和猪流感病毒的流行病学之间的显着差异。观察到的异质性可能会妨碍通过疫苗接种控制猪流感，并表明目前的猪流感疫苗的功效需要重新评估，并且应定期监测猪流感病毒的抗原反应性。

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