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首页> 外文期刊>Vaccine >Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection
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Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection

机译:用福尔马林灭活的流感疫苗接种疫苗可保护小鼠免受致死性化脓性链球菌超感染

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摘要

Intranasal infection with non-lethal influenza A virus (IAV) followed by infection with group A streptococci (GAS) induces invasive, lethal GAS infections, including necrotizing fasciitis, in mice. We demonstrate that subcutaneous immunization of formalin-inactivated IAV vaccine or intranasal immunization of IAV vaccine and cholera toxin protected more than 75% of mice from death by lethal IAV-GAS superinfection. The increased survival rate correlates with increase in IAV neutralizing activity and the levels of serum anti-IAV IgG. Moreover, elimination of IAV from the lungs of vaccinated mice led to depletion of GAS associated with alveolar epithelial cells. These findings suggest that formalin-inactivated IAV vaccine may be useful for prevention of secondary bacterial infections following prior IAV exposure.
机译:鼻内感染非致死性甲型流感病毒(IAV),然后感染A组链球菌(GAS),在小鼠中引起侵袭性,致死性GAS感染,包括坏死性筋膜炎。我们证明,福尔马林灭活的IAV疫苗的皮下免疫或IAV疫苗和霍乱毒素的鼻内免疫可保护超过75%的小鼠免于致命的IAV-GAS重叠感染致死。存活率的提高与IAV中和活性的增加以及血清抗IAV IgG水平的升高有关。此外,从接种小鼠的肺中消除IAV导致与肺泡上皮细胞相关的GAS的消耗。这些发现表明,福尔马林灭活的IAV疫苗可能有助于预防先前暴露于IAV之后的继发性细菌感染。

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