Efficient priming of simian/human immunodeficiency virus (SHIV)-specific T-cell responses with DNA encoding hybrid SHIV/hepatitis B surface antigen particles

Puaux AL; Marsac D; Prost S; Singh MK; Earl P; Moss B; Le Grand R

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Efficient priming of simian/human immunodeficiency virus (SHIV)-specific T-cell responses with DNA encoding hybrid SHIV/hepatitis B surface antigen particles

机译：用编码SHIV /乙型肝炎混合表面抗原颗粒的DNA有效引发猿猴/人类免疫缺陷病毒（SHIV）特异性T细胞反应

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Recent efforts to design an human immunodeficiency virus type 1 (HIV-1) vaccine candidate have focused on means of eliciting anti-viral T-cell responses. We tried to improve the immunogenicity of DNA vaccines by designing hybrid DNA constructs encoding hepatitis B surface antigen (HBsAg) fused to antigenic domains of simian/human immunodeficiency virus (SHIV 89.6P). Immunisation with hybrid DNA induced both effector and long-lasting precursor T-cells. Following boosting with a recombinant modified vaccinia Ankara (rMVA) producing full-length SIV and HIV antigens, it appeared that priming with hybrid DNA had increased virus-specific T-cell responses in terms of both the number of virus-specific IFN-gamma-secreting T-cells and virus-specific lymphoproliferation. After intrarectal challenge with SHIV 89.6P, immunised animals demonstrated early control of SHIV 89.6P replication and stable CD4+ T-cell counts.

机译：设计人类免疫缺陷病毒1型（HIV-1）候选疫苗的最新努力集中在引发抗病毒T细胞反应的手段上。我们试图通过设计编码与乙型肝炎/人类免疫缺陷病毒（SHIV 89.6P）抗原域融合的乙型肝炎表面抗原（HBsAg）的杂合DNA构建物来提高DNA疫苗的免疫原性。用杂交DNA免疫可诱导效应子和持久的前体T细胞。用产生全长SIV和HIV抗原的重组修饰痘苗安卡拉（rMVA）加强免疫后，就病毒特异性IFN-γ-数量而言，似乎用杂合DNA引发增加了病毒特异性T细胞反应。分泌T细胞和病毒特异性淋巴增殖。经SHIV 89.6P直肠内攻击后，免疫动物表现出SHIV 89.6P复制的早期控制和稳定的CD4 + T细胞计数。

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《Vaccine》 |2004年第28期|共11页
作者
Puaux AL; Marsac D; Prost S; Singh MK; Earl P; Moss B; Le Grand R;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Shiv; Rhesus macaque; Dna immunisation; Hbsag; Rhesus-monkeys; Immune-responses; Cd8(+) lymphocytes; Neutralizing; antibodies; Disease progression; Viral replication; Hiv; Infection; Macaques; Hepatitis;

机译：Shiv;猕猴;Dna免疫;Hbsag;猕猴;免疫应答;Cd8（+）淋巴细胞;中和;抗体;疾病进展;病毒复制;HIV;感染;猕猴;肝炎;

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专利

1. Efficient priming of simian/human immunodeficiency virus (SHIV)-specific T-cell responses with DNA encoding hybrid SHIV/hepatitis B surface antigen particles [J] . Puaux AL, Marsac D, Prost S, Vaccine . 2004,第27a28期

机译：用编码SHIV /乙型肝炎混合表面抗原颗粒的DNA有效引发猿猴/人类免疫缺陷病毒（SHIV）特异性T细胞反应
2. Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection. [J] . Motohara M, Ibuki K, Miyake A, Microbes and infection . 2006,第6期

机译：与病原性较低的SHIV感染相比，急性病原性嵌合猿猴-人免疫缺陷病毒（SHIV）感染早期胸腺中T细胞分化受损。
3. Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid [J] . Jean D. Boyer, Tara M. Robinson, Michele A. Kutzler, Proceedings of the National Academy of Sciences of the United States of America . 2007,第47期

机译：用SHIV抗原和IL-15质粒共免疫后猕猴的猿猴/人类免疫缺陷病毒（SHIV）89.6P的保护
4. Purification of a Chinteric Simian - Human Immunodeficiency Virus-Like Nanoparticle from HEK293 Cell Culture [C] . Luisa Pedro and Guilherme N. M. Ferreira European Society of Animal Cell Technology . 2010

机译：从HEK293细胞培养物中纯化了含有Chinteric Simian - 人免疫缺陷病毒样纳米粒子
5. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

机译：人类免疫缺陷病毒1型（HIV-1）的VPU蛋白的跨膜和胞质域在猿猴人类免疫缺陷病毒（SHIV）/猕猴模型的急性CD4 + T细胞丧失和疾病中的作用。
6. Expansion and Exhaustion of T-Cell Responses during Mutational Escape from Long-Term Viral Control in Two DNA/Modified Vaccinia Virus Ankara-Vaccinated and Simian-Human Immunodeficiency Virus SHIV-89.6P-Challenged Macaques [O] . Shanmugalakshmi Sadagopal, Rama Rao Amara, Sunil Kannanganat, 2008

机译：长期逃避病毒控制的两种脱氧核糖核酸/修饰的痘苗病毒安卡拉疫苗和猿猴-人免疫缺陷病毒SHIV-89.6P挑战猕猴的T细胞反应的扩展和耗尽
7. Expansion and Exhaustion of T-Cell Responses during Mutational Escape from Long-Term Viral Control in Two DNA/Modified Vaccinia Virus Ankara-Vaccinated and Simian-Human Immunodeficiency Virus SHIV-89.6P-Challenged Macaques▿ [O] . Sadagopal, Shanmugalakshmi, Amara, Rama Rao, Kannanganat, Sunil, 2008

机译：长期逃避病毒控制的两种脱氧核糖核酸/修饰的痘苗病毒安卡拉疫苗和猿猴-人免疫缺陷病毒SHIV-89.6P挑战的猕猴的T细胞反应的扩展和耗尽。

Efficient priming of simian/human immunodeficiency virus (SHIV)-specific T-cell responses with DNA encoding hybrid SHIV/hepatitis B surface antigen particles

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