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首页> 外文期刊>Vaccine >The V3 loop based multi-epitope polypeptide TAB9 adjuvated with montanideISA720 is highly immunogenic in nonhuman primates and induces neutralizingantibodies against five HIV-1 isolates
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The V3 loop based multi-epitope polypeptide TAB9 adjuvated with montanideISA720 is highly immunogenic in nonhuman primates and induces neutralizingantibodies against five HIV-1 isolates

机译：与montanideISA720修饰的基于V3环的多表位多肽TAB9在非人类灵长类动物中具有高度免疫原性，并诱导针对五种HIV-1分离物的中和抗体

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In a previous work we selected montanide ISA720 (M-ISA720) among different adjuvants for the vaccination with a V3 loop based multi-epitope polypeptide TAB9. In this paper we present the evaluation of the toxicity and immunogenicity of this formulation in non-human primates. TAB9 in M-ISA720 was highly immunogenic in macaques (Macaca fascicularis) inducing antibodies against TAB9 in all animals after one inoculation and a strong anamnestic response after booster injections. Furthermore 97% of the V3 peptides included were recognized by TABB sera. No differences between doses of 200 mu g and 1 mg of TAB9 in M-ISA720 were observed after four immunizations. Neutralizing antibodies against five HIV-1 isolates were detected in most animals. Animals remain healthy throughout the study and did not show lesions at the inoculation site. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 24]
机译：在以前的工作中，我们从不同的佐剂中选择了菊红素ISA720（M-ISA720）进行基于V3环的多表位多肽TAB9的疫苗接种。在本文中，我们介绍了该制剂在非人灵长类动物中的毒性和免疫原性。 M-ISA720中的TAB9在猕猴（macaca fascicularis）中具有高度免疫原性，一次接种后在所有动物中诱导针对TAB9的抗体，并在加强注射后产生强烈的记忆反应。此外，TABB血清可识别97％的V3肽。在四次免疫后，在M-ISA720中未观察到200μg和1mg TAB9的剂量之间的差异。在大多数动物中检测到针对五种HIV-1分离株的中和抗体。动物在整个研究过程中保持健康，并且在接种部位未显示病变。 （C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：24]

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