Immunological properties of FMDV-gP64 fusion proteins expressed on SF9 cell and baculovirus surfaces

Tami C; Peralta A; Barbieri R; Berinstein A; Carrillo E; Taboga O

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Immunological properties of FMDV-gP64 fusion proteins expressed on SF9 cell and baculovirus surfaces

机译：在SF9细胞和杆状病毒表面表达的FMDV-gP64融合蛋白的免疫学性质

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In the present report, we characterized the immune response and the protection conferred by recombinant baculoviruses or infected insect cells expressing the fusions gp64-P1 and gp64-site A FMDV antigens. Mice, vaccinated intraperitoneally with gp64-P1 immunogens, showed a low-antibody response and a variable degree of protection. However, when mice received recombinant baculoviruses or infected insect cells expressing the fusion protein gp64-site A, high-ELISA and seroneutralizing titers (SNT) against FMDV were elicited. All mice immunized with Sf9 cells expressing FMDV site A developed a protective immune response against challenge with virulent FMDV, indicating that the baculovirus display of foreign epitopes is a promising approach to biosynthetic vaccines.

机译：在本报告中，我们表征了表达重组gp64-P1和gp64-位点FMDV抗原的重组杆状病毒或感染的昆虫细胞的免疫应答和保护作用。腹膜内接种gp64-P1免疫原的小鼠表现出低抗体应答和不同程度的保护作用。但是，当小鼠接受重组杆状病毒或表达融合蛋白gp64位点A的感染昆虫细胞时，会引发针对FMDV的高酶联免疫吸附测定和血清滴定度（SNT）。用表达FMDV位点A的Sf9细胞免疫的所有小鼠均产生了针对强毒FMDV攻击的保护性免疫应答，表明杆状病毒展示外源抗原决定簇是一种有前途的生物合成疫苗方法。

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《Vaccine》 |2004年第6期|共6页
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Tami C; Peralta A; Barbieri R; Berinstein A; Carrillo E; Taboga O;
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中图分类卫生标准、卫生检查、医药管理;
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1. Immunological properties of FMDV-gP64 fusion proteins expressed on SF9 cell and baculovirus surfaces [J] . Tami C, Peralta A, Barbieri R, Vaccine . 2004,第6期

机译：在SF9细胞和杆状病毒表面表达的FMDV-gP64融合蛋白的免疫学性质
2. N-linked Glycosylated HN Protein of NDV Strain AF2240 Expressed in Baculovirus-Infected Sf9 Cells [J] . Ong HKA, Omar AR, Tan WS, Journal of Biochemistry, Molecular Biology and Biophysics . 1999,第3a4期

机译：在杆状病毒感染的Sf9细胞中表达的NDV株AF2240的N联糖基化HN蛋白
3. N-linked Glycosylated HN Protein of NDV Strain AF2240 Expressed in Baculovirus-Infected Sf9 Cells [J] . Ong HKA, Omar AR, Tan WS, Journal of Biochemistry, Molecular Biology and Biophysics . 1999,第3a4期

机译：在杆状病毒感染的Sf9细胞中表达的NDV株AF2240的N联糖基化HN蛋白
4. EXPISF™: A CHEMICALLY-DEFINED BACULOVIRUS-BASED EXPRESSION SYSTEM FOR ENHANCED PROTEIN PRODUCTION IN SF9 CELLS [C] . Maya Yovcheva, Sara Barnes, Kenneth Thompson, Conference on vaccine technology VI . 2018

机译：EXPISF™：基于化学的杆状病毒表达系统，用于增强SF9细胞中的蛋白质生产
5. Herpes simplex virus type I (HSV-1)-induced cell fusion: Influence of viral glycoprotein D alleles and cell surface expression of glycosaminoglycans on cell fusion mediated by HSV entry receptors HveA, HveB and HveC. [D] . Terry-Allison, Tracy Lynn. 1999

机译：I型单纯疱疹病毒（HSV-1）诱导的细胞融合：病毒糖蛋白D等位基因和糖胺聚糖的细胞表面表达对HSV进入受体HveA，HveB和HveC介导的细胞融合的影响。
6. Interaction of glucocorticosteroid receptor and wild-type or mutated 90-kDa heat shock protein coexpressed in baculovirus-infected Sf9 cells. [O] . F Cadepond, N Binart, B Chambraud, 1993

机译：糖皮质激素受体与野生型或突变的90 kDa热休克蛋白的相互作用在杆状病毒感染的Sf9细胞中共表达。
7. The method used to culture host cells (Sf9 cells) can affect the qualities of baculovirus budding particles expressing recombinant proteins [O] . Tomomi Hattori, Kohei Nakanishi, Takaaki Mori, 2016

机译：用于培养宿主细胞的方法（SF9细胞）可以影响表达重组蛋白的杆状病毒芽孢杆菌芽孢杆菌的质量

Immunological properties of FMDV-gP64 fusion proteins expressed on SF9 cell and baculovirus surfaces

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