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Tetanus and diphtheria antibodies and response to a booster dose in Brazilian HIV-1-infected women

机译：巴西HIV-1感染妇女的破伤风和白喉抗体及其对加强剂量的反应

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Tetanus and diphtheria (Td) antibodies were studied in HIV-1-infected women during puerperium. HIV group (n = 61) was compared with Control group (n = 101). Twenty-one women from HIV and 13 from Control group who had antibody levels lower than 0.1 IU/mL received a booster with Td vaccine. Antibodies were assessed by double antigen ELISA. Mean tetanus and diphtheria antibody levels from HIV group were lower than those from Control group. Multiple linear regression analysis showed that tetanus and diphtheria antibody levels were decreased by HIV-1-infection, and that was independent of the reduction due to the time interval between last booster and antibody assessment. After a booster dose, both groups had an increase in mean tetanus and diphtheria antibody levels, but in Control group the levels were higher than in HIV group.
机译：在产褥期期间，在感染HIV-1的女性中研究了破伤风和白喉（Td）抗体。将HIV组（n = 61）与对照组（n = 101）进行比较。抗体水平低于0.1 IU / mL的21名来自HIV的女性和13名来自对照组的女性接受了Td疫苗的加强免疫。通过双抗原ELISA评估抗体。 HIV组的平均破伤风和白喉抗体水平低于对照组。多元线性回归分析显示，破伤风和白喉抗体水平因HIV-1感染而降低，并且与上次加强免疫和抗体评估之间的时间间隔所导致的降低无关。加强剂量后，两组的平均破伤风和白喉抗体水平均升高，但对照组的水平高于HIV组。

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