Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)

Castro JF; Bennett JV; Rincon HG; Munoz MT; Sanchez LA; Santos JI

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Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)

机译：三种途径评估成人三联病毒疫苗（MMR）的免疫原性和副作用：皮下和呼吸道（气雾剂）

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Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.

机译：对来自两个相邻卫生中心的成年志愿者进行了麻疹，腮腺炎，风疹疫苗（MMR，印度血清研究所有限公司）的免疫接种，方法是传统注射或通过呼吸道气雾剂注射。抽取基线和疫苗接种后一个月的样品，并同时测定所有三种抗原。疫苗接种后对受试者进行时间相关事件的随访。当在多变量分析中控制基线滴度时，气雾剂途径对麻疹，腮腺炎和风疹更为有效。两组之间的疫苗接种后事件发生频率无统计学差异。似乎有必要进一步评估MMR免疫的气雾剂途径。

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《Vaccine》 |2005年第8期|共6页
作者
Castro JF; Bennett JV; Rincon HG; Munoz MT; Sanchez LA; Santos JI;
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中图分类卫生标准、卫生检查、医药管理;
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1. Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol) [J] . Castro JF, Bennett JV, Rincon HG, Vaccine . 2005,第8期

机译：三种途径评估成人三联病毒疫苗（MMR）的免疫原性和副作用：皮下和呼吸道（气雾剂）
2. Antibody persistence in young adults 1 year after MMR immunization by aerosol or by subcutaneous route. [J] . Diaz-Ortega JL, Bennett JV, Castaneda D, Vaccine . 2010,第44期

机译：气雾剂或皮下途径MMR免疫后1年，年轻人中的抗体持续存在。
3. Aerosolized MMR vaccine: Evaluating potential transmission of components to vaccine administrators and contacts of vaccinees [J] . Diaz-OrtegaJ.-L., BennettJ.V., CastanedaD., Biologicals: Journal of the International Association of Biological Standardization . 2012,第4期

机译：气雾化MMR疫苗：评估疫苗管理和疫苗接触的潜在成分传播
4. Towards Cell Culture-Based Influenza Vaccine Design: Impact of Viral Hemagglutinin N-Glycosylation on Immunogenicity [C] . Hutter J., Rodig J., Hoper D. International Carbohydrate Symposium . 2013

机译：致细胞培养的流感疫苗设计：病毒血凝素N-糖基化对免疫原性的影响
5. A rhesus monkey model of respiratory syncytial virus (RSV) to evaluate the immunogenicity and protective efficacy of a DNA vaccine. [D] . Vaughan, Kerrie Colleen McArthur. 2002

机译：呼吸道合胞病毒（RSV）的恒河猴模型，用于评估DNA疫苗的免疫原性和保护功效。
6. P14-10. Comparable immunogenicity of VRC DNA and rAd5 HIV-1 vaccines delivered by intramuscular subcutaneous and intradermal routes in healthy adults (VRC 011) [O] . JE Ledgerwood, L Novik, ME Enama, 2009

机译：P14-10。在健康成年人中通过肌内皮下和皮内途径提供的VRC DNA和rAd5 HIV-1疫苗的免疫原性相当（VRC 011）
7. First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector–Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults [O] . Paola Cicconi, Claire Jones, Esha Sarkar, 2019

机译：首先是人类随机的研究，评估基于黑猩猩 - 腺病毒-155病毒载体的RSV融合，核衣壳和健康成人的硝基氨基葡萄病毒蛋白的安全性和免疫原性的疫苗的安全性和免疫原性

Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)

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