Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection

Palendira U; Spratt JM; Britton WJ; Triccas JA

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Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection

机译：扩大BCG的抗原库可提高对气溶胶结核分枝杆菌感染的保护作用

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We have developed a strain of the tuberculosis vaccine Mycobacterium bovis bacille Calmette Guerin (BCG) that secretes high levels of a fusion protein comprising the immunodominant Mycobacterium tuberculosis Ag85B and ESAT-6 (BCG85B-ES). Mice vaccinated with BCG85B-ES were significantly better protected in the lung against aerosol infection with virulent M. tuberculosis than animals immunized with control BCG. The growth characteristic of BCG85B-ES in host tissue was identical to control BCG, suggesting the improved protective efficacy was directly related to the expression of the Ag85B-ESAT-6 fusion protein. These results suggest that BCG85B-ES warrants further investigation to determine its suitability to control tuberculosis in humans.

机译：我们已经开发了一种结核病疫苗牛分枝杆菌杆菌卡梅特·格林（BCG）菌株，该菌株分泌高水平的融合蛋白，其中包括免疫优势性结核分枝杆菌Ag85B和ESAT-6（BCG85B-ES）。与用对照BCG免疫的动物相比，接种BCG85B-ES的小鼠在肺部的保护作用更强，可以抵抗强毒结核分枝杆菌的气溶胶感染。 BCG85B-ES在宿主组织中的生长特性与对照BCG相同，这表明改善的保护功效与Ag85B-ESAT-6融合蛋白的表达直接相关。这些结果表明，BCG85B-ES值得进一步研究，以确定其是否适合控制人类的结核病。

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《Vaccine》 |2005年第14期|共6页
作者
Palendira U; Spratt JM; Britton WJ; Triccas JA;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Animals; Antigens; Bacterial genetics immunology; Comparative Study; Mice; Mice; Inbred C57BL; Mycobacterium bovis immunology; Mycobacterium tuberculosis immunology; Tuberculosis immunology microbiology prevention amp; control;

机译：动物;抗原;细菌遗传学免疫学;比较研究;小鼠;小鼠;近交C57BL;牛分枝杆菌免疫学;结核分枝杆菌免疫学;结核菌免疫学微生物防治;

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专利

1. Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection [J] . Palendira U, Spratt JM, Britton WJ, Vaccine . 2005,第14期

机译：扩大BCG的抗原库可提高对气溶胶结核分枝杆菌感染的保护作用
2. Evaluation of immunogenicity and protective efficacy against Mycobacterium tuberculosis infection elicited by recombinant Mycobacterium bovis BCG expressing human Interleukin-12p70 and Early Secretory Antigen Target-6 fusion protein. [J] . Deng Y, Bao L, Yang X Microbiology and Immunology . 2011,第11期

机译：评价表达人白介素12p70和早期分泌抗原Target-6融合蛋白的重组牛分枝杆菌BCG引发的针对结核分枝杆菌感染的免疫原性和保护效果。
3. Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice [J] . Jiuling Wang, Yaqing Qie, Wei Liu, Human vaccines . 2012,第12期

机译：重组BCG分泌抗原85B / Rv3425融合蛋白对小鼠结核分枝杆菌感染的保护作用
4. Mycobacterium tuberculosis Antigen-Specific IL-2R and IP-10 Expression Changes in Chronic Obstructive Pulmonary Disease Patients with in Latent Tuberculosis Infection [C] . Sungyong Bong, Sunghyun Kim, Joo Hwan Hwang, International Molecular Medicine Tri-Conference. . 2016

机译：结核分枝杆菌抗原特异性IL-2R和IP-10表达变化慢性阻塞性肺病患者潜在结核病感染
5. Comparison of the efficacy of intranasal versus subcutaneous bacillus calmette-guerin (BCG) vaccination against challenge with virulent Mycobacterium tuberculosis. [D] . Uppari, Sridhar. 2012

机译：鼻内和皮下卡介苗（BCG）接种疫苗对抗强力结核分枝杆菌攻击的功效比较。
6. Evaluation of Immunogenicity and Protective Efficacy Elicited by Mycobacterium bovis BCG Overexpressing Ag85A Protein against Mycobacterium tuberculosis Aerosol Infection [O] . Zheng Zhong Xu, Xiang Chen, Ting Hu, 2016

机译：牛分枝杆菌BCG过表达Ag85A蛋白对结核分枝杆菌气溶胶感染的免疫原性和保护作用的评价
7. Evaluation of immunogenicity and protective efficacy elicited by Mycobacterium bovis BCG overexpressing Ag85A protein against Mycobacterium tuberculosis aerosol infection [O] . Zheng Zhong Xu, Xiang eChen, Ting eHu, 2016

机译：过量表达ag85a蛋白的牛分枝杆菌BCG对结核分枝杆菌气溶胶感染引起的免疫原性和保护效果的评估

Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection

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