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首页> 外文期刊>Vaccine >Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor
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Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor

机译：对美国皮肤利什曼病无活性疫苗与粒细胞巨噬细胞集落刺激因子的免疫反应

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摘要

The immunological response in healthy subjects to a crude leishmania antigen vaccine (Leishvacin) plus rhGM-CSF without prior Montenegro (DTH) skin testing was evaluated. Fifty-six healthy volunteers received vaccine plus either placebo or rhGM-CSF at day 0, followed by either a vaccine booster or placebo at day 21. IFN-gamma and IL-5 levels were significantly enhanced by day 21. The adjuvant higher percentage of individuals with a significant response to vaccination than the corresponding placebo group. Eighty-six percent of all volunteers were DTH-positive by day 42. Leishvacin is capable of sensitizing lymphocytes from individuals not previously C, exposed to leishmania antigen. Use of rhGM-CSF enhanced the immune response, indicating that it may improve immunological response to the vaccine.
机译：评估了健康受试者对未进行黑山（DTH）皮肤测试的粗制利什曼原虫抗原疫苗（Leishvacin）加rhGM-CSF的免疫反应。 56名健康志愿者在第0天接受了疫苗加安慰剂或rhGM-CSF的治疗，然后在第21天接受了疫苗加强剂或安慰剂的接受。第21天，IFN-γ和IL-5的水平显着提高。与相应的安慰剂组相比，对疫苗接种有明显反应的个体。到第42天，所有志愿者中有86％的DTH阳性。利什曼（Leishvacin）能够敏化暴露于利什曼原虫抗原的非先前C型个体的淋巴细胞。使用rhGM-CSF可以增强免疫反应，表明它可以改善对疫苗的免疫反应。

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