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首页> 外文期刊>Vaccine >A randomized trial demonstrating successful boosting responses following simultaneous aerosols of measles and rubella (MR) vaccines in school age children
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A randomized trial demonstrating successful boosting responses following simultaneous aerosols of measles and rubella (MR) vaccines in school age children

机译：一项随机试验表明，在学龄儿童中同时接种了麻疹和风疹（MR）疫苗气雾剂后，成功增强了免疫应答

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The reactogenicity and immunogenicity of combined measles and rubella (MR) booster vaccination, via aerosol and subcutaneous routes, was assessed in 562 healthy children. Rates of rubella seroconversion and geometric mean titers (GMT) were similar for both routes. Races of measles PN seroconversion, GMT and measles ELISA post-vaccination seropositivity and seroconversion rate were each higher for aerosol vaccine (54%, 3928 IU/l, 99.6 and 98.8%), than for subcutaneous vaccine (7%, 866 IU/l, 92.2 and 82.4%) (P < 0.01). Reactogenicity was higher for subcutaneous vaccine (P < 0.05). This study demonstrates that aerosol vaccine was more immunogenic for measles antibodies, and equally immunogenic for rubella antibodies. Aerosol vaccine was less reactogenic. (C) 2002 Elsevier Science Ltd. All fights reserved. [References: 29]
机译：在562名健康儿童中评估了通过气雾剂和皮下途径联合接种麻疹和风疹（MR）加强疫苗的反应原性和免疫原性。两种路线的风疹血清转化率和几何平均滴度（GMT）相似。气溶胶疫苗（54％，3928 IU / l，99.6和98.8％）的麻疹PN血清转换，GMT和麻疹ELISA的种族分别高于皮下疫苗（7％，866 IU / l）（54％，3928 IU / l，99.6和98.8％） ，92.2和82.4％）（P <0.01）。皮下疫苗的反应原性较高（P <0.05）。这项研究表明，气溶胶疫苗对麻疹抗体的免疫原性更高，对风疹抗体的免疫原性也更高。气溶胶疫苗的反应原性较低。 （C）2002 Elsevier ScienceLtd。保留所有权利。 [参考：29]

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