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Induction and displacement of an alpha helix in the 6725 SERA peptide analogue confers protection against P-falciparum malaria

机译:6725 SERA肽类似物中α螺旋的诱导和置换赋予针对P-恶性疟疾的保护

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摘要

The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by (HNMR)-H-1 to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules
机译:称为丝氨酸重复抗原(SERA)的蛋白质是恶性疟原虫疟疾抗原。在该蛋白中已鉴定出高活性的红细胞结合肽。分析了其中之一6725肽(非免疫原性和非保护性)及其在类似动物中的免疫力和保护活性。通过(HNMR)-H-1研究了这些肽,试图使它们的结构与其生物学功能相关。除了随机结构的6725外,这些肽的螺旋区位置不同。已显示,替换某些氨基酸可诱导其对实验性疟疾的免疫原性和保护性,并改变了其三维(3D)结构,表明此类修饰可能允许更适合免疫系统分子

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