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Immunogenicity of a combined diphtheria-tetanus-acellular pertussis vaccine in adults

机译：成人白喉-破伤风-无细胞百日咳联合疫苗的免疫原性

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Two clinical studies were undertaken to evaluate the immunogenicity of an adult-type dTpa booster vaccine (Boostrix(TM) by Glaxo-SmithKline Biologicals). Blood samples taken prior to vaccination showed that 24.4 and 13.0% of subjects were seronegative for diphtheria and tetanus antibodies, respectively. Moreover, about one-third of the vaccinees had no detectable levels of antibodies to pertussis toxoid (PT) or pertactin (PRN). One month post-vaccination, more than 93% of all individuals, regardless of age or type of vaccine received, had seroprotective antibody levels for diphtheria and tetanus (greater than or equal to0.1 IU/ml). In those individuals vaccinated with the adult-type dTpa vaccine (Boostrix(TM)), more than 98% were found to be seropositive for antibodies to all three pertussis antigens (PT, filamentous haemogluttin (FHA), and PRN). These data suggest that immunity to diphtheria, tetanus and pertussis (DTP) in adults wanes and that booster vaccination with an adult-type combined dTpa vaccine would boost the serological response to diphtheria antitoxin, tetanus antitoxin and antibodies to Bordetella pertussis PT, FHA and PRN
机译：进行了两项临床研究，以评估成人型dTpa加强疫苗（葛兰素史克公司的Boostrix™）的免疫原性。接种疫苗之前采集的血液样本显示，分别有24.4％和13.0％的受试者血清白喉抗体和破伤风抗体阴性。此外，约三分之一的疫苗中没有检测到百日咳类毒素（PT）或百日咳杆菌粘附素（PRN）的抗体水平。疫苗接种后一个月，无论年龄大小或所接受疫苗的种类，有93％以上的个体具有白喉和破伤风的血清保护性抗体水平（大于或等于0.1 IU / ml）。在接种了成人dTpa疫苗（Boostrix™）的那些个体中，发现针对所有三种百日咳抗原（PT，丝状血凝素（FHA）和PRN）的抗体血清阳性率为98％以上。这些数据表明，成年人对白喉，破伤风和百日咳（DTP）的免疫力下降，并且成人联合dTpa疫苗加强疫苗接种将增强对白喉抗毒素，破伤风抗毒素和百日咳博德特氏菌PT，FHA和PRN抗体的血清学应答

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