Induction of mucosal immunity with a replication-defective adenoviralrecombinant

Xiang ZQ.; Ertl HCJ.

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Induction of mucosal immunity with a replication-defective adenoviralrecombinant

机译：复制缺陷型腺病毒重组体诱导粘膜免疫

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A replication-defective adenoviral recombinant expressing the rabies virus glycoprotein was tested for induction of transgene specific central and mucosal antibodies upon systemic inoculation or upon application to the mucosa of the airways, the rectum or the female genital tract. Mice developed serum and mucosal antibody titers to rabies virus upon subcutaneous or intranasal immunization with the latter route favoring induction of genital and intestinal secretion of antibodies of the IgA isotype. Immunization through the mucose of the genital tract or the rectum was inefficient. Mucosal and systemic antibody liters could be increased by intranasal priming followed by a booster immunization with the same construct. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 18]

机译：测试了表达狂犬病病毒糖蛋白的复制缺陷型腺病毒重组体在全身接种或应用于气道，直肠或女性生殖道粘膜后是否诱导了转基因特异性中枢和粘膜抗体。皮下或鼻内免疫后，小鼠对狂犬病毒产生了血清和粘膜抗体滴度，后一种途径有助于诱导IgA同型抗体的生殖器和肠道分泌。通过生殖道或直肠粘液的免疫效率低下。鼻内启动，然后用相同的构建物加强免疫，可以增加粘膜和全身抗体的升数。（C）1999 Elsevier ScienceLtd。保留所有权利。 [参考：18]

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《Vaccine》 |1999年第16期|共6页
作者
Xiang ZQ.; Ertl HCJ.;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Mucosal immunity; Vaccines; Recombinant vaccine; Rabies virus glycoprotein; Herpes simplex virus; Intranasal; immunization; Viral antigens; Antibody responses; Vaccine; Gene; Hepatocytes; Subunit; Hiv 1;

机译：粘膜免疫;疫苗;重组疫苗;狂犬病病毒糖蛋白;单纯疱疹病毒;鼻内;免疫;病毒抗原;抗体反应;疫苗;基因;肝细胞;亚基;HIV 1;

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专利

1. Induction of mucosal immunity with a replication-defective adenoviralrecombinant [J] . Xiang ZQ., Ertl HCJ. Vaccine . 1999,第15a16期

机译：复制缺陷型腺病毒重组体诱导粘膜免疫
2. Two replication-defective adenoviral vaccine vectors for the induction of immune responses to PPRV. [J] . Rojas J. M., Moreno H., Garcia A., Vaccine . 2014,第3期

机译：两种复制缺陷型腺病毒疫苗载体，用于诱导对PPRV的免疫应答。
3. Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. [J] . Flatz L, Hegazy AN, Bergthaler Nature medicine . 2010,第3期

机译：复制缺陷型淋巴细胞膜脑膜炎病毒载体的开发，用于诱导有效的CD8 + T细胞免疫。
4. Counter-regulation in the mucosal immune system and the mechanism of mucosal inflammation [C] . W. STROBER, I. FUSS, A. KITANI Falk Symposium . 2000

机译：粘膜免疫系统的反调节与粘膜炎症的机制
5. Induction of mucosal immunity using virus-like particle based vaccines [D] . Hunter, Zoe 2011

机译：使用病毒样颗粒疫苗诱导粘膜免疫
6. Replication-Defective Adenoviral Vaccine Vector for the Induction of Immune Responses to Dengue Virus Type 2 [O] . Smita Jaiswal, Navin Khanna, S. Swaminathan 2003

机译：复制缺陷型腺病毒疫苗载体用于诱导对2型登革热病毒的免疫应答
7. Influence of Mucosal and Parenteral Immunization with a Replication-Defective Mutant of HSV-2 on Immune Responses and Protection from Genital Challenge [O] . Morrison Lynda A., Da Costa Xavier J., Knipe David M. 1998

机译：HSV-2复制缺陷突变体的粘膜和肠胃外免疫对免疫应答和生殖器攻击的保护作用

Induction of mucosal immunity with a replication-defective adenoviralrecombinant

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