Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720

Walther M; Dunachie S; Keating S; Vuola JM; Berthoud T; Schmidt A; Maier C; Andrews L; Andersen RF; Gilbert S; Poulton I; Webster D; Dubovsky F; Tierney E; Sarpot

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Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720

机译：Seppic ISA 720中配制的促红细胞生成前疟疾候选疫苗ICC-1132的安全性，免疫原性和功效

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ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite protein (CSP), was administered i.m. as a single 50 microg dose in Seppic ISA 720 to 11 volunteers. Local reactogenicity and systemic side effects were acceptable with the predominant finding being mild pain at the injection site. This regimen induced anti-NANP antibodies in 10/11 and modest T cell responses. There was no evidence of protection from experimental challenge with P. falciparum sporozoites. Other formulations and/or multi-dose regimens will be required to enhance the immunogenicity and efficacy of ICC-1132.

机译：ICC-1132是一种重组病毒样颗粒，它由带有B细胞（NANP）和恶性疟原虫环子孢子蛋白（CSP）的两个T细胞表位的修饰的乙型肝炎核心蛋白组成。在Seppic ISA 720中以50微克的单剂量给予11位志愿者。局部反应原性和全身性副作用是可以接受的，主要发现是注射部位的轻度疼痛。该方案在10/11和适度的T细胞应答中诱导抗NANP抗体。没有证据表明恶性疟原虫子孢子具有免受实验攻击的保护作用。需要其他制剂和/或多剂量方案来增强ICC-1132的免疫原性和功效。

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《Vaccine》 |2005年第7期|共8页
作者
Walther M; Dunachie S; Keating S; Vuola JM; Berthoud T; Schmidt A; Maier C; Andrews L; Andersen RF; Gilbert S; Poulton I; Webster D; Dubovsky F; Tierney E; Sarpot;
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中图分类卫生标准、卫生检查、医药管理;
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1. Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720 [J] . Walther M, Dunachie S, Keating S, Vaccine . 2005,第7期

机译：Seppic ISA 720中配制的促红细胞生成前疟疾候选疫苗ICC-1132的安全性，免疫原性和功效
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机译：以单磷酰脂质a，分枝杆菌细胞壁骨架和角鲨烯为佐剂的疟疾子孢子疫苗的安全性，免疫原性和功效

Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720

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