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首页> 外文期刊>Vaccine >A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF)
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A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF)

机译：编码癌胚抗原（CEA）和粒细胞/巨噬细胞集落刺激因子（GM-CSF）遗传融合的DNA疫苗

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摘要

The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T cell and antibody responses specific for CEA. Mice injected with CEA-GMCSF fusion plasmids also developed IgG autoantibodies to GM-CSF. Tumor challenge with the CEA-expressing syngeneic mouse adenocarcinoma line, MC38-CEA-2, showed delayed tumor growth in mice immunized with the CEA-GMCSF fusion plasmids but complete protection in mice immunized with plasmid encoding CEA alone. In contrast, a single low-dose immunization with CEA-GMCSF fusion plasmids provided better tumor protection than low-dose CEA plasmid alone and resulted in lower titers of GM-CSF antibodies.
机译：检查了编码与鼠粒细胞/巨噬细胞集落刺激因子（GM-CSF）融合的人癌胚抗原（CEA）的质粒DNA疫苗的抗肿瘤免疫作用。用CEA-GMCSF融合质粒以三剂高剂量免疫方案免疫C57BL / 6小鼠，导致针对CEA的T细胞和抗体应答。注射了CEA-GMCSF融合质粒的小鼠也产生了针对GM-CSF的IgG自身抗体。表达CEA的同系小鼠腺癌系MC38-CEA-2对肿瘤的攻击显示，在用CEA-GMCSF融合质粒免疫的小鼠中肿瘤生长延迟，但在仅用编码CEA的质粒免疫的小鼠中受到完全保护。相反，与单独的低剂量CEA质粒相比，用CEA-GMCSF融合质粒进行的单次低剂量免疫可提供更好的肿瘤保护，并导致滴度较低的GM-CSF抗体。

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